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Podocyturia as a Diagnostic Marker for Preeclampsia amongst High-Risk Pregnant Patients
Joint Authors
Garry, David
Acharya, Anjali
Mian, Samia
Provenzano, Christopher
Jean-Louis, Pascale
Qipo, Andi
Jim, Belinda
Matos, Tulio
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Urinary podocyte (podocyturia) has been studied as a diagnostic marker for preeclampsia.
We sought to validate its use in preeclampsia and in differentiating it from other high risk pregnancy states.
We studied an obstetric population at high risk to develop preeclampsia (study group) and uncomplicated pregnancies (control group) by analyzing their urine sediment for podocytes within 24 hours of delivery.
Podocytes were identified by immunohistochemistry using the podocyte-specific protein synaptopodin.
Of the 56 patients who were enrolled, 29 patients were diagnosed with preeclampsia, 9 patients had hypertensive conditions such as chronic and gestational hypertension, 6 patients had Type I/II and gestational diabetes mellitus, 3 patients were classified as others, and 9 patients exhibited uncomplicated pregnancies.
Podocyturia was identified in 11 out of 29 (38%) of patients with preeclampsia/eclampsia, 3 out of 9 (33%) with gestational and chronic hypertension, and 3 out of 6 (50%) with Type I/II and gestational diabetes mellitus.
None of the 9 patients (0%) with uncomplicated pregnancies demonstrated podocyturia.
The sensitivity and specificity of podocyturia for preeclampsia were found to be 38% and 70%.
Our study showed that podocyturia does not appear to be a sensitive nor a specific marker to diagnose preeclampsia.
American Psychological Association (APA)
Jim, Belinda& Jean-Louis, Pascale& Qipo, Andi& Garry, David& Mian, Samia& Matos, Tulio…[et al.]. 2012. Podocyturia as a Diagnostic Marker for Preeclampsia amongst High-Risk Pregnant Patients. Journal of Pregnancy،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-513617
Modern Language Association (MLA)
Jim, Belinda…[et al.]. Podocyturia as a Diagnostic Marker for Preeclampsia amongst High-Risk Pregnant Patients. Journal of Pregnancy No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-513617
American Medical Association (AMA)
Jim, Belinda& Jean-Louis, Pascale& Qipo, Andi& Garry, David& Mian, Samia& Matos, Tulio…[et al.]. Podocyturia as a Diagnostic Marker for Preeclampsia amongst High-Risk Pregnant Patients. Journal of Pregnancy. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-513617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513617