Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease : Involvement of the Nrf2-ARE Pathway
Joint Authors
White, Anthony R.
Kanninen, Katja
Malm, Tarja
Koistinaho, Jari
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Specific regions of the Alzheimer's disease (AD) brain are burdened with extracellular protein deposits, the accumulation of which is concomitant with a complex cascade of overlapping events.
Many of these pathological processes produce oxidative stress.
Under normal conditions, oxidative stress leads to the activation of defensive gene expression that promotes cell survival.
At the forefront of defence is the nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that regulates a broad spectrum of protective genes.
Glycogen synthase kinase-3β (GSK-3β) regulates Nrf2, thus making this kinase a potential target for therapeutic intervention aiming to boost the protective activation of Nrf2.
This paper aims to review the neuroprotective role of Nrf2 in AD, with special emphasis on the role of GSK-3β in the regulation of the Nrf2 pathway.
We also examine the potential of inducing GSK-3β by small-molecule activators, dithiocarbamates, which potentially exert their beneficial therapeutic effects via the activation of the Nrf2 pathway.
American Psychological Association (APA)
Kanninen, Katja& White, Anthony R.& Koistinaho, Jari& Malm, Tarja. 2011. Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease : Involvement of the Nrf2-ARE Pathway. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-513670
Modern Language Association (MLA)
Kanninen, Katja…[et al.]. Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease : Involvement of the Nrf2-ARE Pathway. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-513670
American Medical Association (AMA)
Kanninen, Katja& White, Anthony R.& Koistinaho, Jari& Malm, Tarja. Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease : Involvement of the Nrf2-ARE Pathway. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-513670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513670