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Characterisation of Hypertensive Patients with Improved Endothelial Function after Dark Chocolate Consumption
Joint Authors
Neves, Mario Fritsch
Oigman, Wille
d'El-Rei, Jenifer
Medeiros, Fernanda
Burlá, Marcelo
Cunha, Ana Rosa
Burlá, Adriana K.
Virdis, Agostino
Source
International Journal of Hypertension
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Recent findings indicate an inverse relationship between cardiovascular disease and consumption of flavonoids.
We aimed to identify clinical and vascular parameters of treated hypertensive who present beneficial effects of dark chocolate for one-week period on vascular function.
Twenty-one hypertensive subjects, aged 40–65 years, were included in a prospective study with measurement of blood pressure (BP), brachial flow-mediated dilatation (FMD), peripheral arterial tonometry, and central hemodynamic parameters.
These tests were repeated after seven days of eating dark chocolate 75 g/day.
Patients were divided according to the response in FMD: responders (n=12) and nonresponders (n=9).
The responder group presented lower age (54 ± 7 versus 61 ± 6 years, P=0.037), Framingham risk score (FRS) (2.5 ± 1.8 versus 8.1 ± 5.1%, P=0.017), values of peripheral (55 ± 9 versus 63 ± 5 mmHg, P=0.041), and central pulse pressure (PP) (44 ± 10 versus 54 ± 6 mmHg, P=0.021).
FMD response showed negative correlation with FRS (r=−0.60, P=0.014), baseline FMD (r=−0.54, P=0.011), baseline reactive hyperemia index (RHI; r=−0.56, P=0.008), and central PP (r=−0.43, P=0.05).
However, after linear regression analysis, only FRS and baseline RHI were associated with FMD response.
In conclusion, one-week dark chocolate intake significantly improved endothelial function and reduced BP in younger hypertensive with impaired endothelial function in spite of lower cardiovascular risk.
American Psychological Association (APA)
d'El-Rei, Jenifer& Cunha, Ana Rosa& Burlá, Adriana K.& Burlá, Marcelo& Oigman, Wille& Neves, Mario Fritsch…[et al.]. 2013. Characterisation of Hypertensive Patients with Improved Endothelial Function after Dark Chocolate Consumption. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-513671
Modern Language Association (MLA)
d'El-Rei, Jenifer…[et al.]. Characterisation of Hypertensive Patients with Improved Endothelial Function after Dark Chocolate Consumption. International Journal of Hypertension No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-513671
American Medical Association (AMA)
d'El-Rei, Jenifer& Cunha, Ana Rosa& Burlá, Adriana K.& Burlá, Marcelo& Oigman, Wille& Neves, Mario Fritsch…[et al.]. Characterisation of Hypertensive Patients with Improved Endothelial Function after Dark Chocolate Consumption. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-513671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513671