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Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases Are Essential for the Inflammatory Response in Cancer Cells
Author
Source
Journal of Signal Transduction
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Inflammation plays a critical role in the development of cancer.
Matrix Metalloproteinase (MMP) functions in the remodeling of the extracellular matrix that is integral for many normal and pathological processes such as morphogenesis, angiogenesis, tissue repair, and tumor invasion.
The tissue inhibitor of metalloproteinases (TIMPs) family regulates the activity of multifunctional metalloproteinases.
In this paper, we discuss the role and mechanism of MMP and TIMP in regulating inflammation responses in solid tumors.
We discuss the mechanism of MMP and inflammation in melanoma, colon cancer, breast cancer, and prostate cancer.
We highlight the roles of the TIMP-2 in modulating the proinflammatory NF-κB pathway in melanoma and lung caner cells.
Based on the molecular mechanisms of TIMPs and MMPs in inflammation and cancer, we can design new strategies for cancer therapy.
American Psychological Association (APA)
Sun, Jun. 2010. Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases Are Essential for the Inflammatory Response in Cancer Cells. Journal of Signal Transduction،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-513677
Modern Language Association (MLA)
Sun, Jun. Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases Are Essential for the Inflammatory Response in Cancer Cells. Journal of Signal Transduction No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-513677
American Medical Association (AMA)
Sun, Jun. Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases Are Essential for the Inflammatory Response in Cancer Cells. Journal of Signal Transduction. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-513677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513677