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Investigation of Genipin Cross-Linked Microcapsule for Oral Delivery of Live Bacterial Cells and Other Biotherapeutics : Preparation and In Vitro Analysis in Simulated Human Gastrointestinal Model
Joint Authors
Lim, Trisna
Prakash, Satya
Chen, Hongmei
Ouyang, Wei
Martoni, Christopher
Afkhami, Fatemeh
Lawuyi, Bisi
Source
International Journal of Polymer Science
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Oral therapy utilizing engineered microorganisms has shown promise in the treatment of many diseases.
By microencapsulation, viable cells can overcome the harsh gastrointestinal (GI) environment and secrete needed therapeutics into the gut.
These engineered cells should be encased without escaping into the GI tract for safety concerns, thus robust microcapsule membrane is requisite.
This paper examined the GI performance of a novel microcapsule membrane using a dynamic simulated human GI model.
Results showed that the genipin cross-linked alginate-chitosan (GCAC) microcapsules possessed strong resistance to structural disintegration in the simulated GI environment.
Leakage of encapsulated high molecular weight dextran, a model material to be protected during the simulated GI transit, was negligible over 72 h of exposure, in contrast to considerable leakage of dextran from the non-cross-linked counterparts.
These microcapsules did not alter the microflora and enzymatic activities in the simulated human colonic media.
This study suggested the potential of the GCAC microcapsules for oral delivery of live microorganisms and other biotherapeutics.
American Psychological Association (APA)
Chen, Hongmei& Ouyang, Wei& Martoni, Christopher& Afkhami, Fatemeh& Lawuyi, Bisi& Lim, Trisna…[et al.]. 2010. Investigation of Genipin Cross-Linked Microcapsule for Oral Delivery of Live Bacterial Cells and Other Biotherapeutics : Preparation and In Vitro Analysis in Simulated Human Gastrointestinal Model. International Journal of Polymer Science،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-513679
Modern Language Association (MLA)
Chen, Hongmei…[et al.]. Investigation of Genipin Cross-Linked Microcapsule for Oral Delivery of Live Bacterial Cells and Other Biotherapeutics : Preparation and In Vitro Analysis in Simulated Human Gastrointestinal Model. International Journal of Polymer Science No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-513679
American Medical Association (AMA)
Chen, Hongmei& Ouyang, Wei& Martoni, Christopher& Afkhami, Fatemeh& Lawuyi, Bisi& Lim, Trisna…[et al.]. Investigation of Genipin Cross-Linked Microcapsule for Oral Delivery of Live Bacterial Cells and Other Biotherapeutics : Preparation and In Vitro Analysis in Simulated Human Gastrointestinal Model. International Journal of Polymer Science. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-513679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513679