Magnolol Protects against MPTPMPP+-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson’s Disease
Joint Authors
Mitsumoto, Yasuhide
Muroyama, Akiko
Kobayashi, Shota
Lv, Cheng
Fujita, Aya
Fukuyama, Yoshiyasu
Source
International Journal of Quality, Statistics, and Reliability
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Economics & Business Administration
Economy
Abstract EN
The aim of this study is to investigate the role of magnolol in preventing 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP-) induced neurodegeneration in mice and 1-methyl-4-phenylpyridinium ion-(MPP+-) induced cytotoxicity to human neuroblastoma SH-SY5Y cells and to examine the possible mechanisms.
Magnolol (30 mg/kg) was orally administered to C57BL/6N mice once a day for 4 or 5 days either before or after MPTP treatment.
Western blot analysis revealed that MPTP injections substantially decreased protein levels of dopamine transporter (DAT) and tyrosine hydroxylase (TH) and increased glial fibrillary acidic protein (GFAP) levels in the striatum.
Both treatments with magnolol significantly attenuated MPTP-induced decrease in DAT and TH protein levels in the striatum.
However, these treatments did not affect MPTP-induced increase in GFAP levels.
Moreover, oral administration of magnolol almost completely prevented MPTP-induced lipid peroxidation in the striatum.
In human neuroblastoma SH-SY5Y cells, magnolol significantly attenuated MPP+-induced cytotoxicity and the production of reactive oxygen species.
These results suggest that magnolol has protective effects via an antioxidative mechanism in both in vivo and in vitro models of Parkinson’s disease.
American Psychological Association (APA)
Muroyama, Akiko& Fujita, Aya& Lv, Cheng& Kobayashi, Shota& Fukuyama, Yoshiyasu& Mitsumoto, Yasuhide. 2012. Magnolol Protects against MPTPMPP+-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson’s Disease. International Journal of Quality, Statistics, and Reliability،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513683
Modern Language Association (MLA)
Muroyama, Akiko…[et al.]. Magnolol Protects against MPTPMPP+-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson’s Disease. International Journal of Quality, Statistics, and Reliability No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-513683
American Medical Association (AMA)
Muroyama, Akiko& Fujita, Aya& Lv, Cheng& Kobayashi, Shota& Fukuyama, Yoshiyasu& Mitsumoto, Yasuhide. Magnolol Protects against MPTPMPP+-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson’s Disease. International Journal of Quality, Statistics, and Reliability. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513683