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Increased Haematopoietic Supportive Function of USSC from Umbilical Cord Blood Compared to CB MSC and Possible Role of DLK-1
Joint Authors
Kogler, Gesine
Radke, Teja Falk
Kluth, Simone Maria
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Multipotent stromal cells can be isolated from a variety of different tissues in the body.
In contrast to stromal cells from the adult bone marrow (BM) or adipose tissue, cord blood (CB) multipotent stromal cells (MSC) are biologically younger.
Since first being described by our group, delta like 1 homologue (DLK-1) was determined as a discriminating factor between the distinct cord blood-derived subpopulations: the unrestricted somatic stromal cells (USSC), which lack adipogenic differentiation capacity, and the BM MSC-like CB MSC.
In this study, experiments assessing the haematopoiesis-supporting capacity and molecular biological analyses were conducted and clearly confirmed different properties.
Compared to CB MSC, USSC lead to a higher expansion of haematopoietic cells and in addition express significantly higher levels of insulin-like growth factor binding protein 1 (IGFBP1), but lower levels of IGF2.
The data presented here also indicate that DLK-1 might not be the sole factor responsible for the inhibition of adipogenic differentiation potential in USSC but nevertheless indicates a biological diversity among cord blood-derived stromal cells.
American Psychological Association (APA)
Kluth, Simone Maria& Radke, Teja Falk& Kogler, Gesine. 2013. Increased Haematopoietic Supportive Function of USSC from Umbilical Cord Blood Compared to CB MSC and Possible Role of DLK-1. Stem Cells International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-513696
Modern Language Association (MLA)
Kluth, Simone Maria…[et al.]. Increased Haematopoietic Supportive Function of USSC from Umbilical Cord Blood Compared to CB MSC and Possible Role of DLK-1. Stem Cells International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-513696
American Medical Association (AMA)
Kluth, Simone Maria& Radke, Teja Falk& Kogler, Gesine. Increased Haematopoietic Supportive Function of USSC from Umbilical Cord Blood Compared to CB MSC and Possible Role of DLK-1. Stem Cells International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-513696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513696