IgG Placental Transfer in Healthy and Pathological Pregnancies
Joint Authors
Carneiro-Sampaio, Magda
Silveira-Lessa, Ana Lúcia
Zago, Cláudia Augusta
Palmeira, Patricia
Quinello, Camila
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Placental transfer of maternal IgG antibodies to the fetus is an important mechanism that provides protection to the infant while his/her humoral response is inefficient.
IgG is the only antibody class that significantly crosses the human placenta.
This crossing is mediated by FcRn expressed on syncytiotrophoblast cells.
There is evidence that IgG transfer depends on the following: (i) maternal levels of total IgG and specific antibodies, (ii) gestational age, (iii) placental integrity, (iv) IgG subclass, and (v) nature of antigen, being more intense for thymus-dependent ones.
These features represent the basis for maternal immunization strategies aimed at protecting newborns against neonatal and infantile infectious diseases.
In some situations, such as mothers with primary immunodeficiencies, exogenous IgG acquired by intravenous immunoglobulin therapy crosses the placenta in similar patterns to endogenous immunoglobulins and may also protect the offspring from infections in early life.
Inversely, harmful autoantibodies may cross the placenta and cause transitory autoimmune disease in the neonate.
American Psychological Association (APA)
Palmeira, Patricia& Quinello, Camila& Silveira-Lessa, Ana Lúcia& Zago, Cláudia Augusta& Carneiro-Sampaio, Magda. 2011. IgG Placental Transfer in Healthy and Pathological Pregnancies. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-513720
Modern Language Association (MLA)
Palmeira, Patricia…[et al.]. IgG Placental Transfer in Healthy and Pathological Pregnancies. Clinical and Developmental Immunology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-513720
American Medical Association (AMA)
Palmeira, Patricia& Quinello, Camila& Silveira-Lessa, Ana Lúcia& Zago, Cláudia Augusta& Carneiro-Sampaio, Magda. IgG Placental Transfer in Healthy and Pathological Pregnancies. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-513720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513720