Curbing Inflammation through Endogenous Pathways : Focus on Melanocortin Peptides
Joint Authors
Perretti, Mauro
Pitzalis, Costantino
Ahmed, Tazeen J.
Montero-Melendez, Trinidad
Source
International Journal of Inflammation
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The resolution of inflammation is now known to be an active process, armed with a multitude of mediators both lipid and protein in nature.
Melanocortins are peptides endowed with considerable promise with their proresolution and anti-inflammatory effects in preclinical models of inflammatory disease, with tissue protective effects.
These peptides and their targets are appealing because they can be seen as a natural way of inducing these effects as they harness endogenous pathways of control.
Whereas most of the information generated about these mediators derives from several acute models of inflammation (such as zymosan induced peritonitis), there is some indication that these mediators may inhibit chronic inflammation by modulating cytokines, chemokines, and leukocyte apoptosis.
In addition, proresolving mediators and their mimics have often been tested alongside therapeutic protocols, hence have been tested in settings more relevant to real life clinical scenarios.
We provide here an overview on some of these mediators with a focus on melanocortin peptides and receptors, proposing that they may unveil new opportunities for innovative treatments of inflammatory arthritis.
American Psychological Association (APA)
Ahmed, Tazeen J.& Montero-Melendez, Trinidad& Perretti, Mauro& Pitzalis, Costantino. 2013. Curbing Inflammation through Endogenous Pathways : Focus on Melanocortin Peptides. International Journal of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-513744
Modern Language Association (MLA)
Ahmed, Tazeen J.…[et al.]. Curbing Inflammation through Endogenous Pathways : Focus on Melanocortin Peptides. International Journal of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-513744
American Medical Association (AMA)
Ahmed, Tazeen J.& Montero-Melendez, Trinidad& Perretti, Mauro& Pitzalis, Costantino. Curbing Inflammation through Endogenous Pathways : Focus on Melanocortin Peptides. International Journal of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-513744
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513744