![](/images/graphics-bg.png)
Alveolar Overdistension as a Cause of Lung Injury : Differences among Three Animal Species
Joint Authors
Esquivias, Javier
García-Delgado, Manuel
Chamorro-Marín, Virginia
Fernández-Mondéjar, Enrique
Díaz-Monrové, Juan Carlos
Navarrete-Sánchez, Inés
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
This study analyses characteristics of lung injuries produced by alveolar overdistension in three animal species.
Mechanical ventilation at normal tidal volume (10 mL/Kg) and high tidal volume (50 mL/Kg) was applied for 30 min in each species.
Data were gathered on wet/dry weight ratio, histological score, and area of alveolar collapse.
Five out of six rabbits with high tidal volume developed tension pneumothorax, and the rabbit results were therefore not included in the histological analysis.
Lungs from the pigs and rats showed minimal histological lesions.
Pigs ventilated with high tidal volume had significantly greater oedema, higher neutrophil infiltration, and higher percentage area of alveolar collapse than rats ventilated with high tidal volume.
We conclude that rabbits are not an appropriate species for in vivo studies of alveolar overdistension due to their fragility.
Although some histological lesions are observed in pigs and rats, the lesions do not appear to be relevant.
American Psychological Association (APA)
García-Delgado, Manuel& Navarrete-Sánchez, Inés& Chamorro-Marín, Virginia& Díaz-Monrové, Juan Carlos& Esquivias, Javier& Fernández-Mondéjar, Enrique. 2012. Alveolar Overdistension as a Cause of Lung Injury : Differences among Three Animal Species. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-513755
Modern Language Association (MLA)
García-Delgado, Manuel…[et al.]. Alveolar Overdistension as a Cause of Lung Injury : Differences among Three Animal Species. The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-513755
American Medical Association (AMA)
García-Delgado, Manuel& Navarrete-Sánchez, Inés& Chamorro-Marín, Virginia& Díaz-Monrové, Juan Carlos& Esquivias, Javier& Fernández-Mondéjar, Enrique. Alveolar Overdistension as a Cause of Lung Injury : Differences among Three Animal Species. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-513755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513755