Living-Donor Liver Transplantation and Hepatitis C
Joint Authors
Akamatsu, Nobuhisa
Sugawara, Yasuhiko
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hepatitis-C-virus- (HCV-) related end-stage cirrhosis is the primary indication for liver transplantation in many countries.
Unfortunately, however, HCV is not eliminated by transplantation and graft reinfection is universal, resulting in fibrosis, cirrhosis, and finally graft decompression.
In areas with low deceased-donor organ availability like Japan, living-donor liver transplantation (LDLT) is similarly indicated for HCV cirrhosis as deceased-donor liver transplantation (DDLT) in Western countries and accepted as an established treatment for HCV-cirrhosis, and the results are equivalent to those of DDLT.
To prevent graft failure due to recurrent hepatitis C, antiviral treatment with pegylated-interferon and ribavirin is currently considered the most promising regimen with a sustained viral response rate of around 30% to 35%, although the survival benefit of this regimen remains to be investigated.
In contrast to DDLT, many Japanese LDLT centers have reported modified treatment regimens as best efforts to secure first graft, such as aggressive preemptive antiviral treatment, escalation of dosages, and elongation of treatment duration.
American Psychological Association (APA)
Akamatsu, Nobuhisa& Sugawara, Yasuhiko. 2013. Living-Donor Liver Transplantation and Hepatitis C. HPB Surgery،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-513761
Modern Language Association (MLA)
Akamatsu, Nobuhisa& Sugawara, Yasuhiko. Living-Donor Liver Transplantation and Hepatitis C. HPB Surgery No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-513761
American Medical Association (AMA)
Akamatsu, Nobuhisa& Sugawara, Yasuhiko. Living-Donor Liver Transplantation and Hepatitis C. HPB Surgery. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-513761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513761