Matrilin-2 Is a Widely Distributed Extracellular Matrix Protein and a Potential Biomarker in the Early Stage of Osteoarthritis in Articular Cartilage
Joint Authors
Javidiparsijani, Sara
Wang, Yichun
Wang, Guirong
Zhang, Shukun
Liu, Jingshi
Peng, Jinwu
Guo, Yan
Liu, Honggang
Luo, Junming
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In this study, we first generated and characterized a polyclonal antibody against unique domain of matrlin-2 and then used this specific antibody to assess the expression pattern of matrilin-2 by immunohistochemistry.
We found that marilin-2 is widely distributed in the connective tissues of many mouse tissues including heart, colon, penis, esophagus, lung, kidney, tracheal cartilage, developmental bone, and adult bone.
The expression level of matrilin-2 was remarkably increased in the tissues of osteoarthritis developmental articular cartilage, compared to normal healthy tissues.
Furthermore, we determined matrilin-2 expression in specific epithelial cells in stomach and ductal epithelial cells of salivary gland.
In other tissues, the positive signals were mainly located around cardiac muscle cells and Purkinje fibers in the heart; corpus spongiosum in the penis; submucosa in the colon and esophagus; extracellular matrix of cartilage in the tracheal cartilage; and, glomerulus, the basement membrane of distal convoluted tubule and renal matrix in kidney.
These observations indicated that the distribution pattern of matrilin-2 is heterogeneous in each tissue.
Matrilin-2 may play an important role in the communication of matrix to matrix and matrix to cells and will be used as a potential biomarker in the early stage of osteoarthritis of articular cartilage.
American Psychological Association (APA)
Zhang, Shukun& Peng, Jinwu& Guo, Yan& Javidiparsijani, Sara& Wang, Guirong& Wang, Yichun…[et al.]. 2014. Matrilin-2 Is a Widely Distributed Extracellular Matrix Protein and a Potential Biomarker in the Early Stage of Osteoarthritis in Articular Cartilage. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-513775
Modern Language Association (MLA)
Zhang, Shukun…[et al.]. Matrilin-2 Is a Widely Distributed Extracellular Matrix Protein and a Potential Biomarker in the Early Stage of Osteoarthritis in Articular Cartilage. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-513775
American Medical Association (AMA)
Zhang, Shukun& Peng, Jinwu& Guo, Yan& Javidiparsijani, Sara& Wang, Guirong& Wang, Yichun…[et al.]. Matrilin-2 Is a Widely Distributed Extracellular Matrix Protein and a Potential Biomarker in the Early Stage of Osteoarthritis in Articular Cartilage. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-513775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513775