The Role of Natural Killer Cells in Sepsis
Joint Authors
Vivier, Eric
Bléry, Mathieu
Forel, Jean-Marie
Thomas, Guillemette
Chiche, Laurent
Vely, Fréderic
Farnarier, Catherine
Papazian, Laurent
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Severe sepsis and septic shock are still deadly conditions urging to develop novel therapies.
A better understanding of the complex modifications of the immune system of septic patients is needed for the development of innovative immunointerventions.
Natural killer (NK) cells are characterized as CD3−NKp46+CD56+ cells that can be cytotoxic and/or produce high amounts of cytokines such as IFN-γ.
NK cells are also engaged in crosstalks with other immune cells, such as dendritic cells, macrophages, and neutrophils.
During the early stage of septic shock, NK cells may play a key role in the promotion of the systemic inflammation, as suggested in mice models.
Alternatively, at a later stage, NK cells-acquired dysfunction could favor nosocomial infections and mortality.
Standardized biological tools defining patients' NK cell status during the different stages of sepsis are mandatory to guide potential immuno-interventions.
Herein, we review the potential role of NK cells during severe sepsis and septic shock.
American Psychological Association (APA)
Chiche, Laurent& Forel, Jean-Marie& Thomas, Guillemette& Farnarier, Catherine& Vely, Fréderic& Bléry, Mathieu…[et al.]. 2011. The Role of Natural Killer Cells in Sepsis. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-513810
Modern Language Association (MLA)
Chiche, Laurent…[et al.]. The Role of Natural Killer Cells in Sepsis. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-513810
American Medical Association (AMA)
Chiche, Laurent& Forel, Jean-Marie& Thomas, Guillemette& Farnarier, Catherine& Vely, Fréderic& Bléry, Mathieu…[et al.]. The Role of Natural Killer Cells in Sepsis. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-513810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513810