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The Serum S100B Level as a Biomarker of Enteroglial Activation in Patients with Ulcerative Colitis
Joint Authors
Borekci, Elif
Celikbilek, Mehmet
Dogan, Serkan
Yilmaz, Neziha
Tanık, Nermin
Yucesoy, Mehmet
Celikbilek, Asuman
Deniz, Kemal
Sabah, Seda
Baldane, Suleyman
Akin, Yavuz
Ozbakir, Omer
Source
International Journal of Inflammation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Recent studies have demonstrated that enteric glial cells (EGC) participate in the homeostasis of the gastrointestinal tract.
This study investigated whether enteroglial markers, including S100B protein and glial fibrillary acidic protein (GFAP), can serve as noninvasive indicators of EGC activation and disease activity in UC patients.
Methods.
This clinical prospective study included 35 patients with UC and 40 age- and sex-matched controls.
The diagnosis of UC was based on standard clinical, radiological, endoscopic, and histological criteria.
Clinical disease activity was evaluated using the Modified Truelove-Witts Severity Index.
Serum samples were analyzed for human GFAP and S100B using commercial enzyme-linked immunosorbent assay kits.
Results.
GFAP was not detected in the serum of either UC patients or controls (P>0.05).
However, we found a significant (P<0.001) decrease in the serum S100B levels in the UC patients.
No correlation between the serum S100B level and the disease activity or duration was observed (P>0.05).
The serum S100B levels did not differ between UC patients with active disease (24 patients, 68.6%) or in remission (11 patients, 31.4%) (P>0.05).
Conclusions.
Ulcerative colitis patients had significantly lower serum S100B levels, while GFAP was of no diagnostic value in UC patients.
American Psychological Association (APA)
Celikbilek, Asuman& Celikbilek, Mehmet& Sabah, Seda& Tanık, Nermin& Borekci, Elif& Dogan, Serkan…[et al.]. 2014. The Serum S100B Level as a Biomarker of Enteroglial Activation in Patients with Ulcerative Colitis. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-513816
Modern Language Association (MLA)
Celikbilek, Asuman…[et al.]. The Serum S100B Level as a Biomarker of Enteroglial Activation in Patients with Ulcerative Colitis. International Journal of Inflammation No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-513816
American Medical Association (AMA)
Celikbilek, Asuman& Celikbilek, Mehmet& Sabah, Seda& Tanık, Nermin& Borekci, Elif& Dogan, Serkan…[et al.]. The Serum S100B Level as a Biomarker of Enteroglial Activation in Patients with Ulcerative Colitis. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-513816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513816