Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9
Author
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Our immune defense depends on two specialized armed forces.
The innate force acts as an alarm mechanism that senses changes in the microenvironment through the recognition of common microbial patterns by Toll-like receptors (TLR) and NOD proteins.
It rapidly generates an inflammatory response aimed at neutralizing the intruder at the mucosal checkpoint.
The innate arm also communicates this message with more specialized adaptive forces represented by pathogen-specific B cells and T cells.
Interestingly, B cells also express some innate sensors, like TLR7 and TLR9, and may respond to bacterial hypomethylated CpG motifs and single-stranded RNA viruses.
Intracellular nucleic acid sensing TLRs play an important role in the pathogenesis of Systemic Lupus Erythematosus (SLE).
In this review, we describe recent achievements in the development of oligonucleotide—(ODN)-based inhibitors of TLR9 and/or TLR7 signaling.
We categorize these novel therapeutics into Classes G, R, and B based on their cellular and molecular targets.
Several short ODNs have already shown promise as pathway-specific therapeutics for animal lupus.
We envision their future use in human SLE, microbial DNA-dependent sepsis, and in other autoinflammatory diseases.
American Psychological Association (APA)
Lenert, Petar S.. 2010. Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-513826
Modern Language Association (MLA)
Lenert, Petar S.. Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9. Mediators of Inflammation No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-513826
American Medical Association (AMA)
Lenert, Petar S.. Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-513826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513826