Present and Future of EGFR Inhibitors for Head and Neck Squamous Cell Cancer
Joint Authors
Baba, Yuh
Kato, Yasumasa
Tokumaru, Yutaka
Fujii, Masato
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although EGFR is expressed at high levels in head and neck squamous cell carcinomas (HNSCCs) and mutations are extremely rare, monotherapy with EGFR inhibitors has shown limited success.
The PI3kinase/Akt pathway is responsible for cellular survival, and inhibition of phosphatidylinositol (PI) synthesis has antiproliferative, anti-invasive, and antiangiogenesis effects on HNSCC.
Molecular crosstalk has been observed between EGFR and IGF1R signaling through the PI3kinase/Akt pathway in HNSCC, as has molecular crosstalk between the NFκB and STAT3 signaling pathways.
Therefore, the combination of an EGFR antagonist with an agent that inhibits the activation of both Akt and NFκB may overcome resistance to EGFR antagonists in HNSCC.
American Psychological Association (APA)
Baba, Yuh& Fujii, Masato& Tokumaru, Yutaka& Kato, Yasumasa. 2012. Present and Future of EGFR Inhibitors for Head and Neck Squamous Cell Cancer. Journal of Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513833
Modern Language Association (MLA)
Baba, Yuh…[et al.]. Present and Future of EGFR Inhibitors for Head and Neck Squamous Cell Cancer. Journal of Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-513833
American Medical Association (AMA)
Baba, Yuh& Fujii, Masato& Tokumaru, Yutaka& Kato, Yasumasa. Present and Future of EGFR Inhibitors for Head and Neck Squamous Cell Cancer. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513833