Influence of Gut Microbiota on Subclinical Inflammation and Insulin Resistance
Joint Authors
Abdalla Saad, Mario Jose
Carvalho, Bruno Melo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Obesity is the main condition that is correlated with the appearance of insulin resistance, which is the major link among its comorbidities, such as type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular and neurodegenerative diseases, and several types of cancer.
Obesity affects a large number of individuals worldwide; it degrades human health and quality of life.
Here, we review the role of the gut microbiota in the pathophysiology of obesity and type 2 diabetes, which is promoted by a bacterial diversity shift mediated by overnutrition.
Whole bacteria, their products, and metabolites undergo increased translocation through the gut epithelium to the circulation due to degraded tight junctions and the consequent increase in intestinal permeability that culminates in inflammation and insulin resistance.
Several strategies focusing on modulation of the gut microbiota (antibiotics, probiotics, and prebiotics) are being experimentally employed in metabolic derangement in order to reduce intestinal permeability, increase the production of short chain fatty acids and anorectic gut hormones, and promote insulin sensitivity to counteract the inflammatory status and insulin resistance found in obese individuals.
American Psychological Association (APA)
Carvalho, Bruno Melo& Abdalla Saad, Mario Jose. 2013. Influence of Gut Microbiota on Subclinical Inflammation and Insulin Resistance. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-513834
Modern Language Association (MLA)
Carvalho, Bruno Melo& Abdalla Saad, Mario Jose. Influence of Gut Microbiota on Subclinical Inflammation and Insulin Resistance. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-513834
American Medical Association (AMA)
Carvalho, Bruno Melo& Abdalla Saad, Mario Jose. Influence of Gut Microbiota on Subclinical Inflammation and Insulin Resistance. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-513834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513834