From Sprouting Angiogenesis to Erythrocytes Generation by Cancer Stem Cells : Evolving Concepts in Tumor Microcirculation
Joint Authors
Alameddine, Raafat S.
Hamieh, Lana
Shamseddine, Ali I.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Angiogenesis is essential for tumor growth and metastasis.
Over the last decades, a substantial progress has been achieved in defining different patterns of tumor microcirculation.
Sprouting angiogenesis, the oldest model of microcirculation, is the de novo vessel formation from preexisting blood vessels.
Vessel splitting and hijacking, also known, respectively, as intussusception and cooption, are alternative models that account for tumor resistance to antiangiogenic therapy.
In addition to remodeling the microenvironment, the tumor cell can undergo intrinsic changes and survive hypoxic conditions by acquiring stem cell properties.
In line with the concept of pluripotency, tumor cells can form vascular mimicry structures creating their own microcirculation despite a latent vessel growth.
The recent identification of the polyploid giant cancer cells and tumor-derived erythrocytes is the most innovative survival mechanism in hypoxia and provides a potential target for more effective therapies.
American Psychological Association (APA)
Alameddine, Raafat S.& Hamieh, Lana& Shamseddine, Ali I.. 2014. From Sprouting Angiogenesis to Erythrocytes Generation by Cancer Stem Cells : Evolving Concepts in Tumor Microcirculation. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-513838
Modern Language Association (MLA)
Alameddine, Raafat S.…[et al.]. From Sprouting Angiogenesis to Erythrocytes Generation by Cancer Stem Cells : Evolving Concepts in Tumor Microcirculation. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-513838
American Medical Association (AMA)
Alameddine, Raafat S.& Hamieh, Lana& Shamseddine, Ali I.. From Sprouting Angiogenesis to Erythrocytes Generation by Cancer Stem Cells : Evolving Concepts in Tumor Microcirculation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-513838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513838