Influence of Water Quality on Cholesterol-Induced Tau Pathology : Preliminary Data
Joint Authors
Lawmaster, Todd
Ziolkowski, Chuck
Martin, Timothy
Sparks, D. Larry
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The studies employed the cholesterol-fed rabbit model of Alzheimer's disease (AD) to investigate the relationship between AD-like neurofibrillary tangle (NFT) neuropathology and tau protein levels as the main component of NFT.
We measured brain and plasma tau levels and semiquantified NFT-like neuropathology in cholesterol-fed rabbits administered drinking water of varying quality (distilled, tap, and distilled+copper) compared to animals receiving normal chow and local tap water.
Total tau levels in plasma were increased in all cholesterol-fed rabbits compared to animals on normal chow, regardless of quality of water.
In contrast, increased tau in brain and increased AT8 immunoreactive NFT-like lesions were greatest in cholesterol-fed rabbits administered distilled water.
A substantial decrease in brain tau and incidence and density of AT8 immunoreactive NFT-like lesions occurred in cholesterol-fed rabbits administered copper water, and an even greater decrease was observed in cholesterol-fed animals on local tap water.
These studies suggest the possibility that circulating tau could be the source of the tau accumulating in the brain.
American Psychological Association (APA)
Sparks, D. Larry& Ziolkowski, Chuck& Lawmaster, Todd& Martin, Timothy. 2011. Influence of Water Quality on Cholesterol-Induced Tau Pathology : Preliminary Data. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-513860
Modern Language Association (MLA)
Sparks, D. Larry…[et al.]. Influence of Water Quality on Cholesterol-Induced Tau Pathology : Preliminary Data. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-513860
American Medical Association (AMA)
Sparks, D. Larry& Ziolkowski, Chuck& Lawmaster, Todd& Martin, Timothy. Influence of Water Quality on Cholesterol-Induced Tau Pathology : Preliminary Data. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-513860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513860