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STAT3 Regulates Proliferation and Immunogenicity of the Ewing Family of Tumors In Vitro
Joint Authors
Anderson, John
Wallace, Rebecca
Behjati, Sam
Hasan, Fyeza
Bier, Nelly
Sebire, Neil
Basu, B. Piku
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The Ewing sarcoma family of tumors (ESFT) represents an aggressive spectrum of malignant tumour types with common defining histological and cytogenetic features.
To evaluate the functional activation of signal transducer and activator of transcription 3 (STAT3) in ESFT, we evaluated its activation in primary tissue sections and observed the functional consequences of its inhibition in ESFT cell lines.
STAT3 was activated (tyrosine 705-phosphorylated) in 18 out of 31 primary tumours (58%), either diffusely (35%) or focally (23%).
STAT3 was constitutively activated in 3 out of 3 ESFT cell lines tested, and its specific chemical inhibition resulted in complete loss of cell viability.
STAT3 inhibition in ESFT cell lines was associated with several consistent changes in chemokine profile suggesting a role of STAT3 in ESFT in both cell survival and modification of the cellular immune environment.
Together these data support the investigation of STAT3 inhibitors for the Ewing family of tumors.
American Psychological Association (APA)
Behjati, Sam& Basu, B. Piku& Wallace, Rebecca& Bier, Nelly& Sebire, Neil& Hasan, Fyeza…[et al.]. 2012. STAT3 Regulates Proliferation and Immunogenicity of the Ewing Family of Tumors In Vitro. Sarcoma،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-513883
Modern Language Association (MLA)
Behjati, Sam…[et al.]. STAT3 Regulates Proliferation and Immunogenicity of the Ewing Family of Tumors In Vitro. Sarcoma No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-513883
American Medical Association (AMA)
Behjati, Sam& Basu, B. Piku& Wallace, Rebecca& Bier, Nelly& Sebire, Neil& Hasan, Fyeza…[et al.]. STAT3 Regulates Proliferation and Immunogenicity of the Ewing Family of Tumors In Vitro. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-513883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513883