Administration of Harmine and Imipramine Alters Creatine Kinase and Mitochondrial Respiratory Chain Activities in the Rat Brain

Joint Authors

Streck, Emilio Luiz
Quevedo, João
Crippa, J. A. S.
Jeremias, Isabela C.
Stringari, Roberto B.
Jeremias, Gabriela C.
Réus, Gislaine Z.
Ferreira, Gabriela K.
Carvalho-Silva, Milena
Scaini, Giselli
Gonçalves, Cinara L.
Cecílio Hallak, J. E.
Zuardi, Antônio W.

Source

Depression Research and Treatment

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-09-29

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

The present study evaluated mitochondrial respiratory chain and creatine kinase activities after administration of harmine (5, 10, and 15 mg/kg) and imipramine (10, 20, and 30 mg/kg) in rat brain.

After acute treatment occurred an increase of creatine kinase in the prefrontal with imipramine (20 and 30 mg/kg) and harmine in all doses, in the striatum with imipramine (20 and 30 mg/kg) and harmine (5 and 10 mg/kg); harmine (15 mg/kg) decreased creatine kinase.

In the chronic treatment occurred an increase of creatine kinase with imipramine (20 mg/kg), harmine (5 mg/kg) in the prefrontal with imipramine (20 and 30 mg/kg) and harmine (5 and 10 mg/kg) in the striatum.

In the acute treatment, the complex I increased in the prefrontal with harmine (15 mg/kg) and in the striatum with harmine (10 mg/kg); the complex II decreased with imipramine (20 and 30 mg/kg) in the striatum; the complex IV increased with imipramine (30 mg/kg) in the striatum.

In the chronic treatment, the complex I increased with harmine (5 mg/kg) in the prefrontal; the complex II increased with imipramine (20 mg/kg) in the prefrontal; the complex IV increased with harmine (5 mg/kg) in the striatum.

Finally, these findings further support the hypothesis that harmine and imipramine could be involved in mitochondrial function.

American Psychological Association (APA)

Réus, Gislaine Z.& Stringari, Roberto B.& Gonçalves, Cinara L.& Scaini, Giselli& Carvalho-Silva, Milena& Jeremias, Gabriela C.…[et al.]. 2011. Administration of Harmine and Imipramine Alters Creatine Kinase and Mitochondrial Respiratory Chain Activities in the Rat Brain. Depression Research and Treatment،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-513898

Modern Language Association (MLA)

Réus, Gislaine Z.…[et al.]. Administration of Harmine and Imipramine Alters Creatine Kinase and Mitochondrial Respiratory Chain Activities in the Rat Brain. Depression Research and Treatment No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-513898

American Medical Association (AMA)

Réus, Gislaine Z.& Stringari, Roberto B.& Gonçalves, Cinara L.& Scaini, Giselli& Carvalho-Silva, Milena& Jeremias, Gabriela C.…[et al.]. Administration of Harmine and Imipramine Alters Creatine Kinase and Mitochondrial Respiratory Chain Activities in the Rat Brain. Depression Research and Treatment. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-513898

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-513898