Lgr4 in Ocular Development and Glaucoma
Joint Authors
Liu, Mingyao
Siwko, Stefan
Weng, Jinsheng
Lai, Li
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4, also called GPR48) plays a key role in multiple developmental processes, and mice lacking Lgr4 display anterior segment dysgenesis leading to early-onset glaucomatous retinal ganglion cell loss as well as defective eyelid formation.
This paper will review Lgr4 signaling and its regulation of the Axenfeld-Rieger syndrome gene Pitx2, a crucial developmental transcription factor.
In addition, Wnt signaling plays an important role in eye development, with Norrin functioning to activate the Wnt receptor Frizzled 4 required for proper retinal vascularization.
Recent discoveries identifying Lgr4 as a receptor for Norrin highlight the potential for Lgr4 function in retinal vascularization.
Finally, several unanswered questions impeding a full understanding of Lgr4 in glaucoma are considered as avenues for further research.
American Psychological Association (APA)
Siwko, Stefan& Lai, Li& Weng, Jinsheng& Liu, Mingyao. 2013. Lgr4 in Ocular Development and Glaucoma. Journal of Ophthalmology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-513907
Modern Language Association (MLA)
Siwko, Stefan…[et al.]. Lgr4 in Ocular Development and Glaucoma. Journal of Ophthalmology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-513907
American Medical Association (AMA)
Siwko, Stefan& Lai, Li& Weng, Jinsheng& Liu, Mingyao. Lgr4 in Ocular Development and Glaucoma. Journal of Ophthalmology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-513907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513907