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Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity : A Biochemical and Histological Study
Joint Authors
Kose, Evren
Sarihan, Ediz
Vardi, Nigar
Turkoz, Yusuf
Ekinci, Nihat
Sapmaz, Hilal Irmak
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The effects of montelukast against methotrexate-induced liver damage were investigated.
35 Wistar albino female rats were divided into 5 groups as follows: group I: control; group II: montelukast (ML); group III: methotrexate (Mtx); group IV: montelukast treatment after methotrexate application (Mtx + ML); group V: montelukast treatment before methotrexate application (ML + Mtx).
At the end of the experiment, the liver tissues of rats were removed.
Malondialdehyde (MDA), myeloperoxidase (MPO), and reduced glutathione levels were determined from liver tissues.
In addition, the liver tissues were examined histologically.
MDA and MPO levels of Mtx group were significantly increased when compared to control group.
In Mtx + ML group, these parameters were decreased as compared to Mtx group.
Mtx injection exhibited major histological alterations such as eosinophilic staining and swelling of hepatocytes.
The glycogen storage in hepatocytes was observed as decreased by periodic acid schiff staining in Mtx group as compared to controls.
ML treatment did not completely ameliorate the lesions and milder degenerative alterations as loss of the glycogen content was still present.
It was showed that montelukast treatment after methotrexate application could reduce methotrexate-induced experimental liver damage.
American Psychological Association (APA)
Kose, Evren& Sapmaz, Hilal Irmak& Sarihan, Ediz& Vardi, Nigar& Turkoz, Yusuf& Ekinci, Nihat. 2012. Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity : A Biochemical and Histological Study. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-513910
Modern Language Association (MLA)
Kose, Evren…[et al.]. Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity : A Biochemical and Histological Study. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-513910
American Medical Association (AMA)
Kose, Evren& Sapmaz, Hilal Irmak& Sarihan, Ediz& Vardi, Nigar& Turkoz, Yusuf& Ekinci, Nihat. Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity : A Biochemical and Histological Study. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-513910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513910