Gene Therapy : A Potential Approach for Cancer Pain
Joint Authors
Handy, Chalonda R.
Krudy, Christina
Boulis, Nicholas
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Chronic pain is experienced by as many as 90% of cancer patients at some point during the disease.
This pain can be directly cancer related or arise from a sensory neuropathy related to chemotherapy.
Major pharmacological agents used to treat cancer pain often lack anatomical specificity and can have off-target effects that create new sources of suffering.
These concerns establish a need for improved cancer pain management.
Gene therapy is emerging as an exciting prospect.
This paper discusses the potential for viral vector-based treatment of cancer pain.
It describes studies involving vector delivery of transgenes to laboratory pain models to modulate the nociceptive cascade.
It also discusses clinical investigations aimed at regulating pain in cancer patients.
Considering the prevalence of pain among cancer patients and the growing potential of gene therapy, these studies could set the stage for a new class of medicines that selectively disrupt nociceptive signaling with limited off-target effects.
American Psychological Association (APA)
Handy, Chalonda R.& Krudy, Christina& Boulis, Nicholas. 2011. Gene Therapy : A Potential Approach for Cancer Pain. Pain Research and Treatment،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-513924
Modern Language Association (MLA)
Handy, Chalonda R.…[et al.]. Gene Therapy : A Potential Approach for Cancer Pain. Pain Research and Treatment No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-513924
American Medical Association (AMA)
Handy, Chalonda R.& Krudy, Christina& Boulis, Nicholas. Gene Therapy : A Potential Approach for Cancer Pain. Pain Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-513924
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513924