Chiral Recognition by Fluorescence : One Measurement for Two Parameters
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
This outlook describes two strategies to simultaneously determine the enantiomeric composition and concentration of a chiral substrate by a single fluorescent measurement.
One strategy utilizes a pseudoenantiomeric sensor pair that is composed of a 1,1′-bi-2-naphthol-based amino alcohol and a partially hydrogenated 1,1′-bi-2-naphthol-based amino alcohol.
These two molecules have the opposite chiral configuration with fluorescent enhancement at two different emitting wavelengths when treated with the enantiomers of mandelic acid.
Using the sum and difference of the fluorescent intensity at the two wavelengths allows simultaneous determination of both concentration and enantiomeric composition of the chiral acid.
The other strategy employs a 1,1′-bi-2-naphthol-based trifluoromethyl ketone that exhibits fluorescent enhancement at two emission wavelengths upon interaction with a chiral diamine.
One emission responds mostly to the concentration of the chiral diamine and the ratio of the two emissions depends on the chiral configuration of the enantiomer but independent of the concentration, allowing both the concentration and enantiomeric composition of the chiral diamine to be simultaneously determined.
These strategies would significantly simplify the practical application of the enantioselective fluorescent sensors in high-throughput chiral assay.
American Psychological Association (APA)
Yu, Shanshan& Pu, Lin. 2014. Chiral Recognition by Fluorescence : One Measurement for Two Parameters. Advances in Chemistry،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-513933
Modern Language Association (MLA)
Yu, Shanshan& Pu, Lin. Chiral Recognition by Fluorescence : One Measurement for Two Parameters. Advances in Chemistry No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-513933
American Medical Association (AMA)
Yu, Shanshan& Pu, Lin. Chiral Recognition by Fluorescence : One Measurement for Two Parameters. Advances in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-513933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513933