![](/images/graphics-bg.png)
Protective Effect of Acacia nilotica (L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats
Joint Authors
Sakthivel, Kunnathur Murugesan
Guruvayoorappan, Chandrasekaran
Kannan, Narayanan
Source
Advances in Pharmacological Sciences
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The potential biological functions of A.
nilotica have long been described in traditional system of medicine.
However, the protective effect of A.
nilotica on acetaminophen-induced hepatotoxicity is still unknown.
The present study attempted to investigate the protective effect of A.
nilotica against acetaminophen-induced hepatic damage in Wistar rats.
The biochemical liver functional tests Alanine transaminase (ALT), Aspartate transaminase (AST), Alkaline phosphatase (ALP), total bilirubin, total protein, oxidative stress test (Lipid peroxidation), antioxidant parameter glutathione (GSH), and histopathological changes were examined.
Our results show that the pretreatment with A.
nilotica (250 mg/kg·bw) orally revealed attenuation of serum activities of ALT, AST, ALP, liver weight, and total bilirubin levels that were enhanced by administration of acetaminophen.
Further, pretreatment with extract elevated the total protein and GSH level and decreased the level of LPO.
Histopathological analysis confirmed the alleviation of liver damage and reduced lesions caused by acetaminophen.
The present study undoubtedly provides a proof that hepatoprotective action of A.
nilotica extract may rely on its effect on reducing the oxidative stress in acetaminophen-induced hepatic damage in rat model.
American Psychological Association (APA)
Kannan, Narayanan& Sakthivel, Kunnathur Murugesan& Guruvayoorappan, Chandrasekaran. 2013. Protective Effect of Acacia nilotica (L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats. Advances in Pharmacological Sciences،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-513937
Modern Language Association (MLA)
Kannan, Narayanan…[et al.]. Protective Effect of Acacia nilotica (L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats. Advances in Pharmacological Sciences No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-513937
American Medical Association (AMA)
Kannan, Narayanan& Sakthivel, Kunnathur Murugesan& Guruvayoorappan, Chandrasekaran. Protective Effect of Acacia nilotica (L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats. Advances in Pharmacological Sciences. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-513937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513937