Naturally Occurring Compounds Elicit HIV-1 Replication in Chronically Infected Promonocytic Cells
Joint Authors
Barquero, Andrea Alejandra
Alché, Laura Edith
Riva, Diego Ariel
Dávola, María Eugenia
Mersich, Susana Esther
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Since antiretroviral therapy suppresses but does not eradicate HIV-1 infection, methods to purge viral reservoirs are required.
Many strategies involve the reactivation of chronically HIV infected cells to induce the expression of integrated viral genome.
In this study, five bioactive compounds, the plant derivatives 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM), nordihydroguaiaretic acid (NDGA), and curcumin (Cur) and the synthetic stigmasterol analogs (22S,23S)-22,23-dihydroxystigmast-4-en-3-one (compound 1) and (22S,23S)-3β-bromo-5α,22,23-trihydroxystigmastan-6-one (compound 2), were evaluated for their ability to elicit HIV replication in promonocytic (U1) and lymphocytic (H9+) HIV-1 chronically infected cells.
The results revealed that natural compounds CDM, NDGA, and Cur were able to increase HIV-1 p24 antigen, determined by ELISA, only in latently infected promonocytic cells.
CDM would reactivate HIV from latency by modulating the release of IL-6 and TNF-α, since the amount of both cytokines measured through ELISA significantly increased in U1 treated cells.
Besides, NDGA increased ROS production, which might be related to the increase on p24 level observed in NDGA treated U1.
These findings suggest that CDM, NDGA, and Cur might be candidates for further studies on latency-reversing therapeutics to eliminate latently HIV-1 reservoirs.
American Psychological Association (APA)
Barquero, Andrea Alejandra& Dávola, María Eugenia& Riva, Diego Ariel& Mersich, Susana Esther& Alché, Laura Edith. 2014. Naturally Occurring Compounds Elicit HIV-1 Replication in Chronically Infected Promonocytic Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-513964
Modern Language Association (MLA)
Barquero, Andrea Alejandra…[et al.]. Naturally Occurring Compounds Elicit HIV-1 Replication in Chronically Infected Promonocytic Cells. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-513964
American Medical Association (AMA)
Barquero, Andrea Alejandra& Dávola, María Eugenia& Riva, Diego Ariel& Mersich, Susana Esther& Alché, Laura Edith. Naturally Occurring Compounds Elicit HIV-1 Replication in Chronically Infected Promonocytic Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-513964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513964