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Effect of Honey and Eugenol on Ehrlich Ascites and Solid Carcinoma
Joint Authors
Mondhe, Dilip
Jaganathan, Saravana Kumar
Wani, Z. A.
Mandal, Mahitosh
Pal, Harish C.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Ehrlich ascites carcinoma is a spontaneous murine mammary adenocarcinoma adapted to ascites form and carried in outbred mice by serial intraperitoneal (i/p) passages.
The previous work from our laboratory showed that honey having higher phenolic content was potent in inhibiting colon cancer cell proliferation.
In this work, we extended our research to screen the antitumor activity of two selected honey samples and eugenol (one of the phenolic constituents of honey) against murine Ehrlich ascites and solid carcinoma models.
Honey containing higher phenolic content was found to significantly inhibit the growth of Ehrlich ascites carcinoma as compared to other samples.
When honey containing higher phenolic content was given at 25% (volume/volume) intraperitoneally (i/p), the maximum tumor growth inhibition was found to be 39.98%.
However, honey was found to be less potent in inhibiting the growth of Ehrlich solid carcinoma.
On the other hand, eugenol at a dose of 100 mg/kg i/p was able to inhibit the growth of Ehrlich ascites by 28.88%.
In case of solid carcinoma, eugenol (100 mg/kg; i/p) showed 24.35% tumor growth inhibition.
This work will promote the development of honey and eugenol as promising candidates in cancer chemoprevention.
American Psychological Association (APA)
Jaganathan, Saravana Kumar& Mondhe, Dilip& Wani, Z. A.& Pal, Harish C.& Mandal, Mahitosh. 2010. Effect of Honey and Eugenol on Ehrlich Ascites and Solid Carcinoma. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-513971
Modern Language Association (MLA)
Jaganathan, Saravana Kumar…[et al.]. Effect of Honey and Eugenol on Ehrlich Ascites and Solid Carcinoma. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-513971
American Medical Association (AMA)
Jaganathan, Saravana Kumar& Mondhe, Dilip& Wani, Z. A.& Pal, Harish C.& Mandal, Mahitosh. Effect of Honey and Eugenol on Ehrlich Ascites and Solid Carcinoma. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-513971
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513971