Tissue Distribution and Associated Toxicological Effects of Decabrominated Diphenyl Ether in Subchronically Exposed Male Rats
Joint Authors
Hu, Guocheng
Luo, Xiaojun
Mai, Bixian
Wang, Fuxin
Wang, Jianshe
Dai, Jiayin
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Concerns about decabrominated diphenyl ether (BDE-209) have arisen recently due to its increasing concentrations in the environment.
We investigated the tissue concentration, distribution, and the debromination of BDE-209 after oral exposure, using rats as a model.
Three groups of male rats were administrated by oral gavage with corn oil containing 0, 10, or 50 mg/kg bw/day of BDE-209 over 90 days.
After exposure, BDE-209 and its metabolites levels in the liver, kidney, and adipose of the rats were measured.
The mRNA expression levels of cytochrome P450 (CYP) enzymes in liver, serum thyroid hormone levels, and open-field tests were also measured.
BDE-209 and several octa- and nona-BDE congeners were detected in the tissues of the dosed rats, indicating that BDE-209 was bioavailable and biotransformative in male rats.
BDE-209 and its debrominated congeners had no mRNA level effect on selective genes from the CYP family in the liver or on the spontaneous behavior of adult male rats.
Conversely, the level of thyroid hormone, total triiodothyronine (T3) in rats from the dosed treatments increased significantly compared to the control group.
American Psychological Association (APA)
Wang, Fuxin& Wang, Jianshe& Hu, Guocheng& Luo, Xiaojun& Mai, Bixian& Dai, Jiayin. 2012. Tissue Distribution and Associated Toxicological Effects of Decabrominated Diphenyl Ether in Subchronically Exposed Male Rats. ISRN Toxicology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-513978
Modern Language Association (MLA)
Wang, Fuxin…[et al.]. Tissue Distribution and Associated Toxicological Effects of Decabrominated Diphenyl Ether in Subchronically Exposed Male Rats. ISRN Toxicology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-513978
American Medical Association (AMA)
Wang, Fuxin& Wang, Jianshe& Hu, Guocheng& Luo, Xiaojun& Mai, Bixian& Dai, Jiayin. Tissue Distribution and Associated Toxicological Effects of Decabrominated Diphenyl Ether in Subchronically Exposed Male Rats. ISRN Toxicology. 2012. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-513978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513978