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Traditional Chinese Medicine Tang-Luo-Ning Ameliorates Sciatic Nerve Injuries in Streptozotocin-Induced Diabetic Rats
Joint Authors
Li, Min-Zhou
Wang, Jin-Yang
Zhou, Hui
Gao, Yan-Bin
Zhang, Tao-Jing
Li, Bu-Man
Zou, Da-Wei
Zhu, Zhi-Yao
Ma, Ming-Fei
Zhang, Na
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetic peripheral neuropathy (DPN) is a common microvascular complication of diabetes associated with high disability rate and low quality of life.
Tang-Luo-Ning (TLN) is an effective traditional Chinese medicine for the treatment of DPN.
To illustrate the underlying neural protection mechanisms of TLN, the effect of TLN on electrophysiology and sciatic nerve morphology was investigated in a model of streptozotocin-induced DPN, as well as the underlying mechanism.
Sciatic motor nerve conduction velocity and digital sensory nerve conduction velocity were reduced in DPN and were significantly improved by TLN or α-lipoic acid at 10 and 20 weeks after streptozotocin injection.
It was demonstrated that TLN intervention for 20 weeks significantly alleviated pathological injury as well as increased the phosphorylation of ErbB2, Erk, Bad (Ser112), and the mRNA expression of neuregulin 1 (Nrg1), GRB2-associated binding protein 1 (Gab1), and mammalian target of rapamycin (Mtor) in injured sciatic nerve.
These novel therapeutic properties of TLN to promote Schwann cell survival may offer a promising alternative medicine for the patients to delay the progression of DPN.
The underlying mechanism may be that TLN exerts neural protection effect after sciatic nerve injury through Nrg1/ErbB2→Erk/Bad Schwann cell survival signaling pathway.
American Psychological Association (APA)
Zou, Da-Wei& Gao, Yan-Bin& Zhu, Zhi-Yao& Zhou, Hui& Zhang, Tao-Jing& Li, Bu-Man…[et al.]. 2013. Traditional Chinese Medicine Tang-Luo-Ning Ameliorates Sciatic Nerve Injuries in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-514019
Modern Language Association (MLA)
Zou, Da-Wei…[et al.]. Traditional Chinese Medicine Tang-Luo-Ning Ameliorates Sciatic Nerve Injuries in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-514019
American Medical Association (AMA)
Zou, Da-Wei& Gao, Yan-Bin& Zhu, Zhi-Yao& Zhou, Hui& Zhang, Tao-Jing& Li, Bu-Man…[et al.]. Traditional Chinese Medicine Tang-Luo-Ning Ameliorates Sciatic Nerve Injuries in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-514019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-514019