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PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response
Joint Authors
Isibasi, Armando
Alpuche-Aranda, Celia
Valero-Pacheco, Nuriban
Arriaga-Pizano, Lourdes
Sánchez-Torres, Luvia Enid
Mora-Velandia, Luz María
Ferat-Osorio, Eduardo
López-Macías, Constantino
Bonifaz, Laura
Villasís-Keever, Miguel Ángel
Pastelin-Palacios, Rodolfo
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
PD-L1 expression plays a critical role in the impairment of T cell responses during chronic infections; however, the expression of PD-L1 on T cells during acute viral infections, particularly during the pandemic influenza virus (A(H1N1)pdm09), and its effects on the T cell response have not been widely explored.
We found that A(H1N1)pdm09 virus induced PD-L1 expression on human dendritic cells (DCs) and T cells, as well as PD-1 expression on T cells.
PD-L1 expression impaired the T cell response against A(H1N1)pdm09 by promoting CD8+ T cell death and reducing cytokine production.
Furthermore, we found increased PD-L1 expression on DCs and T cells from influenza-infected patients from the first and second 2009 pandemic waves in Mexico City.
PD-L1 expression on CD8+ T cells correlated inversely with T cell proportions in patients infected with A(H1N1)pdm09.
Therefore, PD-L1 expression on DCs and T cells could be associated with an impaired T cell response during acute infection with A(H1N1)pdm09 virus.
American Psychological Association (APA)
Valero-Pacheco, Nuriban& Arriaga-Pizano, Lourdes& Ferat-Osorio, Eduardo& Mora-Velandia, Luz María& Pastelin-Palacios, Rodolfo& Villasís-Keever, Miguel Ángel…[et al.]. 2013. PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-514020
Modern Language Association (MLA)
Valero-Pacheco, Nuriban…[et al.]. PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response. Clinical and Developmental Immunology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-514020
American Medical Association (AMA)
Valero-Pacheco, Nuriban& Arriaga-Pizano, Lourdes& Ferat-Osorio, Eduardo& Mora-Velandia, Luz María& Pastelin-Palacios, Rodolfo& Villasís-Keever, Miguel Ángel…[et al.]. PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-514020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-514020