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Postnatal Cytomegalovirus Exposure in Infants of Antiretroviral-Treated and Untreated HIV-Infected Mothers
Joint Authors
Ehlinger, Elizabeth P.
Swamy, Geeta K.
Westreich, Daniel J.
Denny, Thomas N.
Meyer, Sarah A.
Kalilani, Linda
Patel, Emily
Permar, Sallie R.
Lovingood, Rachel V.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
HIV-1 and CMV are important pathogens transmitted via breastfeeding.
Furthermore, perinatal CMV transmission may impact growth and disease progression in HIV-exposed infants.
Although maternal antiretroviral therapy reduces milk HIV-1 RNA load and postnatal transmission, its impact on milk CMV load is unclear.
We examined the relationship between milk CMV and HIV-1 load (4–6 weeks postpartum) and the impact of antiretroviral treatment in 69 HIV-infected, lactating Malawian women and assessed the relationship between milk CMV load and postnatal growth in HIV-exposed, breastfed infants through six months of age.
Despite an association between milk HIV-1 RNA and CMV DNA load (0.39 log10 rise CMV load per log10 rise HIV-1 RNA load, 95% CI 0.13–0.66), milk CMV load was similar in antiretroviral-treated and untreated women.
Higher milk CMV load was associated with lower length-for-age (−0.53, 95% CI: −0.96, −0.10) and weight-for-age (−0.40, 95% CI: −0.67, −0.13) Z-score at six months in exposed, uninfected infants.
As the impact of maternal antiretroviral therapy on the magnitude of postnatal CMV exposure may be limited, our findings of an inverse relationship between infant growth and milk CMV load highlight the importance of defining the role of perinatal CMV exposure on growth faltering of HIV-exposed infants.
American Psychological Association (APA)
Meyer, Sarah A.& Westreich, Daniel J.& Patel, Emily& Ehlinger, Elizabeth P.& Kalilani, Linda& Lovingood, Rachel V.…[et al.]. 2014. Postnatal Cytomegalovirus Exposure in Infants of Antiretroviral-Treated and Untreated HIV-Infected Mothers. Infectious Diseases in Obstetrics and Gynecology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-514025
Modern Language Association (MLA)
Meyer, Sarah A.…[et al.]. Postnatal Cytomegalovirus Exposure in Infants of Antiretroviral-Treated and Untreated HIV-Infected Mothers. Infectious Diseases in Obstetrics and Gynecology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-514025
American Medical Association (AMA)
Meyer, Sarah A.& Westreich, Daniel J.& Patel, Emily& Ehlinger, Elizabeth P.& Kalilani, Linda& Lovingood, Rachel V.…[et al.]. Postnatal Cytomegalovirus Exposure in Infants of Antiretroviral-Treated and Untreated HIV-Infected Mothers. Infectious Diseases in Obstetrics and Gynecology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-514025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-514025