Estimation the concentration of Il-23, and Il-17a in the sera of patients with psoriasis in Baghdad City

Abstract EN

Psoriasis is a common, chronic, disfiguring, inflammatory, hyperproliferation, and abnormal differentiation of keratinocyte, in which both genetic and environmental influences have a critical role.

The study was designed to detection the levels of IL-23 and IL-17A among psoriatic patients compared with healthy group, also studied the correlation between them and some parameter such as:-age of onset and severity of psoriatic patients.

Fifty psoriatic patients were selected randomly from both sexes with ages from (10-70) years.

Patients were diagnosed clinically by dermatologist.

Sera samples of both groups were collected from all individuals for the estimation levels of IL-23 and IL-17A by ELISA technique.

All mean values sera levels (IL-23 96.74 pg / mL and 6.56 pg / mL for IL-17A) of patients were significantly higher than those of controls (18.74 and 3.01 pg / mL for IL-23and IL-17A respectively).

There was a high significant in levels of patients sera of IL-23 and IL-17A, in compared with healthy control group according to these normal values.

Furthermore, there was a significant correlation between the levels of IL-23, and age of disease onset among psoriatic patients.

In contrast there was no significant association between the severity & interleukins (Il-23 and Il-17A).

Emerging data in humans reveals a critical contribution of IL-23 and IL-17A in the pathogenesis of psoriasis.

The IL-23 and IL-17A pathways were atherapeutic targets for biologic agents and systemic therapies in psoriasis treatment.