Cancer : some genetic considerations
Author
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 16, Issue 1 (31 Mar. 2015), pp.1-10, 10 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2015-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Malignant transformation of normal cells to cancer cells represents an enigmatic phenomenon because of the many ambiguous controversies embodied within most of its aspects.
Within a clinical context, cancer, with very few exceptions, is a dreadful disease that ends lethally.
Within a biological context, however, cancer is a peculiar biosystem that has its own rules that regulate the actions / interactions / structure and behavior of its components.
Unfortunately, the majority of these rules are, still, unknown.
The current disappointing situation as regards research trials aiming at constructing effective treatments for cancer might be attributed, in part, to incomplete recognition of the significant differences between these two contexts of malignant transformation.
Although the peculiar characteristics of cancer as a self-dependent biosystem are well studied and well defined, the basic dilemma of malignant transformation continues to exist : we know, largely, how things happen but we do not know, to any extent, why they happen.
Though the logic that motivates researches aiming at formulating genetic therapies for cancer is quite reasonable, as cancer is primarily a genetic alteration, lack of essential basic knowledge regarding the different aspects of this alteration adjourn successful radical cure of cancer.
Till comprehensive disclosure of the underlying mechanisms regulating growth / progression / metastasis and survival of malignant cells is attained, treatments of cancer based on different strategic concepts, viz.
proteomic therapies rather than genetic therapies, might, hopefully, be the best approaches available in the fight against cancer in the current as well as in the coming era.
American Psychological Association (APA)
Salim, Muhammad Sad Zaghlul. 2015. Cancer : some genetic considerations. The Egyptian Journal of Medical Human Genetics،Vol. 16, no. 1, pp.1-10.
https://search.emarefa.net/detail/BIM-517551
Modern Language Association (MLA)
Salim, Muhammad Sad Zaghlul. Cancer : some genetic considerations. The Egyptian Journal of Medical Human Genetics Vol. 16, no. 1 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-517551
American Medical Association (AMA)
Salim, Muhammad Sad Zaghlul. Cancer : some genetic considerations. The Egyptian Journal of Medical Human Genetics. 2015. Vol. 16, no. 1, pp.1-10.
https://search.emarefa.net/detail/BIM-517551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 10
Record ID
BIM-517551