ACE dd genotype associated with the female chronic kidney disease patients of tamilnadu population

Abstract EN

Background : The Renin-Angiotensin System (RAS) is an important regulator for blood pressure and kidney disease.

The level of vaso active peptide Angiotensin-II is mainly determined by the RAS enzyme angiotensin converting enzyme-1 (ACE-1).

Aim : To investigate the association of ACE I / D polymorphism and Chronic Kidney Disease (CKD) in south India.

Methods : In the present study, we have collected CKD patients (n = 147) and control subjects (n = 211) from Tamilnadu.

Genotyping was carried out by polymerase chain reaction (PCR) on the basis of allele specific primers.

Results : The DD genotype is associated with the female population (OR-CI = 2.40 (1.05–5.51), p = 0.04) as compared to the male population (OR-CI = 0.75 (0.37-1.51), p = 0.42).

Further, we found the over representation of ‘‘I’’-allele (homozygous II and heterozygous ID) in unaffected males [OR (CI)- 0.58 (0.32-1.04), p = 0.07] which suggests its protective role in male population.

Conclusion : The DD genotype of ACE is associated with CKD in south India.