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Synthesis of some new 2'-amino-2-fluoro-5'-oxo-1'-(4-phenylthiazole-2-yl)-1', 4' ,5', 6', 7', 8'-hexahydro-3, 4'-biquinoline-3'-carbonitrile derivatives and biological evaluation as antimicrobial agents
Joint Authors
Source
Journal of Saudi Chemical Society
Issue
Vol. 19, Issue 1 (31 Jan. 2015), pp.73-82, 10 p.
Publisher
Publication Date
2015-01-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
A facile one-pot synthesis of 20-amino-2-fluoro-50-oxo-10-(4-phenylthiazol-2-yl)- 10,40,50,60,70,80-hexahydro-3,40-biquinoline-30-carbonitrile derivatives was synthesized in one pot by condensing various 2-fluoroquinoline-3-carbaldehyde 1a–d, enaminones 2a–c and malononitrile or ethylcynoacetate 3a–b in ethanol.
All the compounds were characterized by IR, 1H NMR, 13C NMR spectra and elemental analysis.
All the synthesized compounds were screened for their antibacterial activity against Gram positive bacterial species Streptococcus pneumoniae, Bacillus subtilus and Clostridium tetani, Gram negative bacterial species Escherichia coli, Salmonella typhi and Vibrio cholerae and fungicidal activity against Candida albicans and Aspergillus fumigates.
American Psychological Association (APA)
Shah, Amish& Raj, Dilipsinh. 2015. Synthesis of some new 2'-amino-2-fluoro-5'-oxo-1'-(4-phenylthiazole-2-yl)-1', 4' ,5', 6', 7', 8'-hexahydro-3, 4'-biquinoline-3'-carbonitrile derivatives and biological evaluation as antimicrobial agents. Journal of Saudi Chemical Society،Vol. 19, no. 1, pp.73-82.
https://search.emarefa.net/detail/BIM-517896
Modern Language Association (MLA)
Shah, Amish& Raj, Dilipsinh. Synthesis of some new 2'-amino-2-fluoro-5'-oxo-1'-(4-phenylthiazole-2-yl)-1', 4' ,5', 6', 7', 8'-hexahydro-3, 4'-biquinoline-3'-carbonitrile derivatives and biological evaluation as antimicrobial agents. Journal of Saudi Chemical Society Vol. 19, no. 1 (Jan. 2015), pp.73-82.
https://search.emarefa.net/detail/BIM-517896
American Medical Association (AMA)
Shah, Amish& Raj, Dilipsinh. Synthesis of some new 2'-amino-2-fluoro-5'-oxo-1'-(4-phenylthiazole-2-yl)-1', 4' ,5', 6', 7', 8'-hexahydro-3, 4'-biquinoline-3'-carbonitrile derivatives and biological evaluation as antimicrobial agents. Journal of Saudi Chemical Society. 2015. Vol. 19, no. 1, pp.73-82.
https://search.emarefa.net/detail/BIM-517896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 81-82
Record ID
BIM-517896