Comparison of the effects of eicosapentaenoic acid with docosahexaenoic acid on the level of serum lipoproteins in Helicobacter pylori : a randomized clinical trial
Joint Authors
Baghestani, Ahmad Rida
Shidfar, Farzad
Agha, Shahram
Khandouzi, Nafisah
Husayni, Sharieh
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 17, Issue 1 (31 Jan. 2015), pp.1-8, 8 p.
Publisher
Publication Date
2015-01-31
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : Helicobacter pylori infection is the most common chronic bacterial infection around the world and an important cause of gastrointestinal disorders, which might be involved in the pathogenesis of some extragastrointestinal disturbances as well as changes in serum lipid profile.
Hypolipemic properties of omega-3 fatty acids have been studied in several studies.
Objectives : The present study aimed to compare the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on the level of serum lipoproteins in H.
pylori.
Patients and Methods : In a randomized, double-blinded, placebo-controlled clinical trial in Iran, 105 Helicobacter pylori were randomly allocated to receive 2 g of daily EPA (35 patients), DHA (35 patients), or medium-chain triglyceride (MCT) oil as placebo (33 patients) along with conventional tetra-drug H.
pylori eradication regimen for 12 weeks.
Results : From 105 included patients, 97 (31 in EPA, 33 in DHA, and 33 in control groups) completed the study and were included in final analysis.
The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and the ratios of TG / HDL-C, TC / HDL-C, and LDL-C / HDL-C were not significantly different among the three groups, while the level of triglyceride (TG) was statistically different.
DHA (-16.6 ± 30.34) and control (+ 15.32 ± 56.47) groups were statistically different with regard to changes in TG levels (P = 0.000).
Conclusions : There was no difference between the effects of 2 g of EPA or DHA supplementation for 12 weeks on the levels of total cholesterol, LDL-C, HDL-C, TC / HDL-C, TG / HDL-C, and LDL-C / HDL-C ; however, it had a desirable effect on the level of TG in a way that the effect of DHA was clearer.
American Psychological Association (APA)
Agha, Shahram& Shidfar, Farzad& Khandouzi, Nafisah& Baghestani, Ahmad Rida& Husayni, Sharieh. 2015. Comparison of the effects of eicosapentaenoic acid with docosahexaenoic acid on the level of serum lipoproteins in Helicobacter pylori : a randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 17, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-519703
Modern Language Association (MLA)
Agha, Shahram…[et al.]. Comparison of the effects of eicosapentaenoic acid with docosahexaenoic acid on the level of serum lipoproteins in Helicobacter pylori : a randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 17, no. 1 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-519703
American Medical Association (AMA)
Agha, Shahram& Shidfar, Farzad& Khandouzi, Nafisah& Baghestani, Ahmad Rida& Husayni, Sharieh. Comparison of the effects of eicosapentaenoic acid with docosahexaenoic acid on the level of serum lipoproteins in Helicobacter pylori : a randomized clinical trial. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-519703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-519703