Inhibitory effect of cinnamon cassia against candida albicans growth in vitro and in vivo

Abstract EN

The inhibitory effect of Cinnamon cassia against Candida albicans which isolated from cases of sore mouth in vitro and in vivo was studied.

The results of determining inhibitory effect of alcohol and aqueous extract of Cinnamon against C.

albicans according to well diffusion method showed that Cinnamon extract had the best effect at 50 % concentration with inhibition zone reached to (23) millimeter in aqueous extract and (20) millimeter in alcohol extract while the less effect was observe at 10 % concentration which reached to (11) millimeter in aqueous extracts and (9) millimeter in alcohol extract.

The outcome of in vivo study (histological examination) clarified that C.

albicans caused clinical pathological effect in mice tissue organs (liver, intestine, and kidney) when administrated orally by 1.5 x 10 8 cfu / ml C.

albicans that effect decrease by orally inoculated with 5 mg / ml of the aqueous Cinnamon extract.

The results reflect the ability of cinnamon to reduce certain clinical pathological change in mice organs, with promising encourage to use the Cinnamon as biotherapeutic agents against C.

albicanas infections.