Efficacy of sliver nanoparticle against pathogenic yeast : cryptococcus neoformans invivo

Abstract EN

The objective of this study was to clarify the antifungal efficiency of silver nanoparticles (SNPs) against one of pathogenic yeast, Cryptococcus neoformans that causes pulmonary cryptococcosis.

Nostril experimental exposure of male albino rats to a dose of untreated yeast suspension and adose of treated yeast with SNPs, amphoterin B, and SNPs combined with amphoterine B (gi, gii, giii and giv) respectively.

Results show that SNPs have high antifungal activity against Cryptococcus neoformans, this is indicated by results of histological effects which show that the histological changes that emerged in lung tissues in control group (gi) had eased or disappeared and these tissues began to rectore natural forms when treated with SNPs and antifungal (gi, giii, giv).

Also, there are a significant increase in IFN-g levels and (WBC, RBC, PLT) count in control group (gi) compared with treated groups (gii, giii, giv), this confirms the effectiveness of inhibitory of SNPs.