Detection of BRCA1 2 gene mutation rate among women in Hilla Province
Joint Authors
al-Shibli, Ifad Karim
Abd al-Razzaq, Muhammad Sabri
Muhsin, Muhammad Abbud
Bearem, Wala Nuri
Source
Issue
Vol. 11, Issue 4 (31 Dec. 2014), pp.869-876, 8 p.
Publisher
University of Babylon College of Medicine
Publication Date
2014-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Topics
Abstract AR
يعتبر سرطان الثدي من أهم ـسباب الوفاة في المجتمع.
يعتقد بأن ربع النساء في العالم بالإمكان أن يصبن بسرطان الثدي في أي فترة من حياتهن.
سرطان الثدي من أكثر الأمراض السرطانية شيوعا.
تلعب الطفرات الجينية التي تحدث في جينات BRCA1 و BRCA2 دورآ مهمآ في الكثير من حالات سرطان الثدي.
هذه الجينات لها دور أساسي في الحفاظ على المادة الوراثية من التلف و إعادة تصليحها.
تهدف هذه الدراسة إلى التحري عن مدى انتشار طفرات معينة في المجتمع من خلال دراسة جينية على النساء العراقيات عن طريق التحليل الوراثي لأربعة مجاميع شملت المرضى المصابين بسرطان الثدي، أقرباء من الدرجة الأولى، ناس أصحاء و مرضى مصابين بأورام حميدة في الثدي.
أظهرت نتائج الدراسة نسبة عالية و غير متوقعة من الطفرات الجينية غالبيتها لدى المريضات بسرطان الثدي.
Abstract EN
Background : breast cancer is one of the leading causes of death among women.
One-fourth of women will be affected with cancer at some point in their lives.
Breast cancer is the most prevalent malignancy in women.
Mutations in breast cancer susceptibility genes BRCA1 and BRCA2 account for the majority of breast cancer cases.
BRCA1 and BRCA2 are tumor suppressor genes that repair and correct errors in DNA, act as sensors of DNA damage and participate in the DNA repair processes.
Aim : to illustrate the role of and analyzing the types and frequencies of the most common BRCA1, BRCA2 mutations in different groups of local Iraqi women.
Materials and methods : This is a case-control study design.
A total of forty women were chosen for the genetic study which was performed to detect BRCA1 and BRCA2 mutations, DNA was amplified by polymerase chain reaction (PCR), exon 2 and 20 of BRCA1 and exon 11 of BRCA2 genes, using a specific primer pairs and PCR conditions in four groups of Babylonian populations, including patients with breast cancer, healthy control people, first degree relatives, and patients with benign breast tumors.
Results : The overall frequency of BRCA genes mutation was more often detected among breast cancer patients than other groups in the study (P = 0.05).
Conclusions : There was a surprising high degree of BRCA gene mutation carriage rate, BRCA gene mutations were found to have a relatively high frequency (up to 75 %) among breast cancer patients in the study.
American Psychological Association (APA)
Bearem, Wala Nuri& Abd al-Razzaq, Muhammad Sabri& Muhsin, Muhammad Abbud& al-Shibli, Ifad Karim. 2014. Detection of BRCA1 2 gene mutation rate among women in Hilla Province. Medical Journal of Babylon،Vol. 11, no. 4, pp.869-876.
https://search.emarefa.net/detail/BIM-520635
Modern Language Association (MLA)
Bearem, Wala Nuri…[et al.]. Detection of BRCA1 2 gene mutation rate among women in Hilla Province. Medical Journal of Babylon Vol. 11, no. 4 (2014), pp.869-876.
https://search.emarefa.net/detail/BIM-520635
American Medical Association (AMA)
Bearem, Wala Nuri& Abd al-Razzaq, Muhammad Sabri& Muhsin, Muhammad Abbud& al-Shibli, Ifad Karim. Detection of BRCA1 2 gene mutation rate among women in Hilla Province. Medical Journal of Babylon. 2014. Vol. 11, no. 4, pp.869-876.
https://search.emarefa.net/detail/BIM-520635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 875-876
Record ID
BIM-520635