Serum interleukine 35 in Iraqi female patients with newly diagnosed of rheumatoid arthritis

Abstract EN

Background : Rheumatoid arthritis (RA) characterized by local and systemic effects of inflammation has a wide range of biochemical markers implicated directly or indirectly to its pathogenesis.

Objective : To evaluate interlukine 35 (IL-35) in Iraqi females with newly diagnosed RA and to assess its contribution in the disease process.

Patients and method : Serum of (55 Females) of newly diagnosed RA and 23 healthy Females were used to estimate their interlukine levels.

Results : Females of RA showed a significant increase in the levels of interleukine 35 (IL-35) and in the levels of High Sensitivity C-Reactive Protein (lis CRP).

While there were no significant changes in the level of alkaline phosphatase (ALP) and calcium (Ca).

The correlation between IL-35 and each of hs CRP, ALP and Ca (-ve) were non-significant (r = -0.066, -0.04271 and -0.103) respectively.

Conclusion : This is the first study to show the elevation of serum levels of IL-35 in Iraqi female patients with newly diagnosed RA which indicates that IL- 35 may be a good biomarker for early RA.