Urodynamic effects of various alpha blockers used for treatment of benign prostatic obstruction

Abstract EN

Objectives: we aimed to evaluate the effect of a-blockers on the urodynamic parameters of bladder outlet obstruction (BOO) and to know when to shift to more aggressive interventional procedures.

Patients and Methods: ninety patients having benign prsotatic obstruction (BPO) were divided into three groups that received Doxazosin (GI), Alfuzosin (Gil) and Tamsulosin (GUI)- Scores of symptoms, pressure/flow (P/F) studies and ultrasound estimated bladder weight (UEBW) were evaluated before and one year after therapy.

Results: Symptom scores and all parameters of P/F studies showed significant improvement after one year of therapy, in all groups.

No significant differences were detected between treatment groups.

UEBW was insignificantly decreased after therapy.

4.4% of patients were shifted to transurethral resection of the prostate (TURP).

Conclusion: a-blockers usedfor treating BPO are an effective modality of treatment not only through improving symptoms, but also through changing the P/F parameters in favour of relief of BOO.

UEBW may be a promising tool for monitoring the effect of therapy.

Key words: Benign prostatic hyperplasia- a-blockers-urodynamics, ultrasound estimated bladder weight