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Computer-assisted isobolographic analysis of interaction between diclofenac and neostigmine for antinociceptive activity in experimental animals
Other Title(s)
دراسة نشاط عقار النيوستجمين كمسكن للألم عند إعطائه وحدة و مع عقار الديكلوفيناك في حيوانات التجارب
Joint Authors
al-Dasuqi, Ihab Said
Salim, Safaa Yusuf
Source
Issue
Vol. 28, Issue 2 (31 May. 2004), pp.17-24, 8 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2004-05-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
It is well recognized that Nonsteroidal anti-inflammatory drugs (NSAIDs) produce their antinociceptive action through inhibition of cyclooxygenase enzymes.
It has been found that cholinergic agonists are also antinociceptive.
The main objective of the present study was to evaluate the possible interaction between neostigmine and diclofenac in mice by the acetic acid writhing test.
Intraperitoneal administration of neostigmine and diclofenac at different antinociceptive doses allowed to develop dose response curves for each of them and calculation of corresponding ED50s.
The interactions of neostigmine with diclofenac were evaluated by isobolographic analysis after concomitant intraperitoneal administration of both drugs at fixed ratios of their ED50s.
The combinations of both drugs were found synergistic by isobolographic analysis.
Calculation of interaction index a as an alternative method to isobolographic analysis of drug interaction gave the same result of synergistic interaction for antinociception between the two drugs when concurrently given.
The synergistic interaction between neostigmine and diclofenac could be of clinical importance especially in chronic pain through reduction of analgesic doses and .consequently, adverse effects of given analgesics.
American Psychological Association (APA)
al-Dasuqi, Ihab Said& Salim, Safaa Yusuf. 2004. Computer-assisted isobolographic analysis of interaction between diclofenac and neostigmine for antinociceptive activity in experimental animals. Assiut Medical Journal،Vol. 28, no. 2, pp.17-24.
https://search.emarefa.net/detail/BIM-53043
Modern Language Association (MLA)
al-Dasuqi, Ihab Said& Salim, Safaa Yusuf. Computer-assisted isobolographic analysis of interaction between diclofenac and neostigmine for antinociceptive activity in experimental animals. Assiut Medical Journal Vol. 28, no. 2(May 2004), pp.17-24.
https://search.emarefa.net/detail/BIM-53043
American Medical Association (AMA)
al-Dasuqi, Ihab Said& Salim, Safaa Yusuf. Computer-assisted isobolographic analysis of interaction between diclofenac and neostigmine for antinociceptive activity in experimental animals. Assiut Medical Journal. 2004. Vol. 28, no. 2, pp.17-24.
https://search.emarefa.net/detail/BIM-53043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p.23-24
Record ID
BIM-53043