Serum auto-antibodies in juvenile rheumatoid arthritis
Joint Authors
Atyyah, Jamal
Hafiz, Muhammad M.
al-Batouty, Muhammad Fathi
Shaltut, Ali
Hawas, Samiyah
Hawas, Salah
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 28, Issue 2 (30 Apr. 2001), pp.471-486, 16 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2001-04-30
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Topics
Abstract EN
Objectives: We investigated the relationship between the serum levels of autoantibodies in juvenile rheumatoid arthritis (JRA) to evaluate the diagnostic value of each serological marker and of associations of markers with disease activity.
Methods: The study was conducted on sixty JRA patients (42 girls, and 18 boys) and 60 controls matching in age and sex.
The patients were classified as pauciarticular (24, 40%), polyarticular (27, 45%), and systemic onset (9,15%).
Nine autoantibodies (AFA, AKA, ANA, ANCA, ANTIKU, APF, dsDNA, ssDNA, PDA) were detected and correlated with disease onset and activity markers as well as HLA-DR typing, alleles being done with PCR.
To find out correlations between autoantibodies and disease character, we categorized the patients either active (41,68.3%) or in remission (19,31.7%).
Results: The levels of autoantibodies was significantly higher in JRA active group than in remission, (p<0.0001).
No significant correlation was found between autoantibodies and HLA-DR typing.
The frequencies of HLA-DR8, DR6, and DR5 were significantly higher among JRA group as compared to normal controls.
There was a significant correlation between dsDNA and morning stiffness, ssDNA, EAM, ESR and MS.
Conclusions: The level of autoantibodies differed between active JRA and patients in remission.
These markers were prognostic in predicting disease outcome.
American Psychological Association (APA)
Hafiz, Muhammad M.& Atyyah, Jamal& al-Batouty, Muhammad Fathi& Shaltut, Ali& Hawas, Samiyah& Hawas, Salah. 2001. Serum auto-antibodies in juvenile rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation،Vol. 28, no. 2, pp.471-486.
https://search.emarefa.net/detail/BIM-53225
Modern Language Association (MLA)
Hafiz, Muhammad M.…[et al.]. Serum auto-antibodies in juvenile rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation Vol. 28, no. 2 (Apr. 2001), pp.471-486.
https://search.emarefa.net/detail/BIM-53225
American Medical Association (AMA)
Hafiz, Muhammad M.& Atyyah, Jamal& al-Batouty, Muhammad Fathi& Shaltut, Ali& Hawas, Samiyah& Hawas, Salah. Serum auto-antibodies in juvenile rheumatoid arthritis. Egyptian Rheumatology and Rehabilitation. 2001. Vol. 28, no. 2, pp.471-486.
https://search.emarefa.net/detail/BIM-53225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 483-486
Record ID
BIM-53225