Combination of angiotensin converting enzyme insertion deletion (I D) (rs4646994) and VEGF polymorphism (+405 G C ; rs2010963) synergistically associated with the development, of albuminuria in Iranian patients with type 2 diabetes
Joint Authors
Nakhjavani, Manuchihr
Fathi, Muhammad
Nikzamir, Abd al-Rahim
Yekaninejad, Mir Said
Esteghamati, Ali Rida
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 17, Issue 2 (28 Feb. 2015), pp.1-6, 6 p.
Publisher
Publication Date
2015-02-28
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and vascular endothelial growth factor (VEGF) polymorphisms have been shown to associate with diabetic nephropathy (DN).
Objectives : We examined the hypothesis that ACE-D and VEGF-G alleles act synergistically in association with DN, in patients with type 2 diabetes mellitus (T2DM).
Patients and Methods : The VEGF (rs2010963) and ACE (rs4646994) genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 490 T2DM patients.
Diabetic patients were classified as T2DM patients with and without albuminuria (control).
The PCR and RFLP were used to detect the VEGF and ACE alleles.
Results : A total of 255 consecutive patients with T2DM and microalbuminuria (Group A) and 235 patients with T2DM and normoalbuminuria (Group B) were included in the study.
In univariate analysis, the groups were statistically similar for all variables, except for glycated hemoglobin (HbA1c) (P = 0.034), and the frequency of ACE (P = 0.015) and VEGF (P = 0.006) genotypes.
Our study showed that the VEGF-G and ACE-D alleles are independently associated with the development of nephropathy.
According to our data, the combination of these two risk factors had a significant synergistic effect on the risk of microalbuminuria development.
Conclusions : Our study indicated that ACE-D and VEGF-G alleles can be an independent risk factor for microalbominuria in T2DM patients.
American Psychological Association (APA)
Fathi, Muhammad& Nikzamir, Abd al-Rahim& Esteghamati, Ali Rida& Nakhjavani, Manuchihr& Yekaninejad, Mir Said. 2015. Combination of angiotensin converting enzyme insertion deletion (I D) (rs4646994) and VEGF polymorphism (+405 G C ; rs2010963) synergistically associated with the development, of albuminuria in Iranian patients with type 2 diabetes. Iranian Red Crescent Medical Journal،Vol. 17, no. 2, pp.1-6.
https://search.emarefa.net/detail/BIM-533189
Modern Language Association (MLA)
Fathi, Muhammad…[et al.]. Combination of angiotensin converting enzyme insertion deletion (I D) (rs4646994) and VEGF polymorphism (+405 G C ; rs2010963) synergistically associated with the development, of albuminuria in Iranian patients with type 2 diabetes. Iranian Red Crescent Medical Journal Vol. 17, no. 2 (Feb. 2015), pp.1-6.
https://search.emarefa.net/detail/BIM-533189
American Medical Association (AMA)
Fathi, Muhammad& Nikzamir, Abd al-Rahim& Esteghamati, Ali Rida& Nakhjavani, Manuchihr& Yekaninejad, Mir Said. Combination of angiotensin converting enzyme insertion deletion (I D) (rs4646994) and VEGF polymorphism (+405 G C ; rs2010963) synergistically associated with the development, of albuminuria in Iranian patients with type 2 diabetes. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 2, pp.1-6.
https://search.emarefa.net/detail/BIM-533189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-533189