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Monoamine oxidase a gene polymorphisms and bipolar disorder in Iranian population
Joint Authors
Amir Abbadi, Muhammad Rida Islami
Asfahani, Zubaydah Rajezi
Davari-Ashtiani, Rozita
Khademi, Mo-Mojgan
Emamalizadeh, Babak
Movafagh, Abu al-Fadl
Sadr, Said
Arabgol, Fariba
Darwish, Husayn
Razjoyan, Katayoon
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 17, Issue 2 (28 Feb. 2015), pp.1-5, 5 p.
Publisher
Publication Date
2015-02-28
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Bipolar disorder (BPD) is a common and severe mood disorder.
Although genetic factors have important rolesin the etiology of bipolar disorder, no specific gene has been identified in relation to this disorder.
Monoamine oxidase gene is suggested to be associated with bipolar disorder in many studies.
Objectives : This study aimed to investigatethe role of MAOA gene polymorphisms in the etiology of bipolar disorder in Iranian population.
Patients and Methods: This study is a case-control study, with convenient sampling.
Three common polymorphisms, a CA microsatellite, a VNTR, and a RFLP were typed in 156 bipolar patients and 173 healthy controls.
Patients were chosen from Imam Hossein General Hospital, Psychiatry Ward (Tehran/Iran).
Controlsamples for this study consisted of 173 healthy individuals recruitedby convenient sampling.
Allelic distributions of these polymorphisms were analyzed in bipolar and control groups to investigate any association with MAOA gene.
Results : Significant associations were observed regarding MAOA-CA (P = 0.016) and MAOA-VNTR (P = 0.004) polymorphisms in the bipola females.
There was no association between MAOA-RFLP and bipolar disorder.
Conclusions : The obtained results confirm some previous studies regardinga gender specific association of MAOA gene with the bipolar disorder.
American Psychological Association (APA)
Asfahani, Zubaydah Rajezi& Davari-Ashtiani, Rozita& Khademi, Mo-Mojgan& Emamalizadeh, Babak& Movafagh, Abu al-Fadl& Sadr, Said…[et al.]. 2015. Monoamine oxidase a gene polymorphisms and bipolar disorder in Iranian population. Iranian Red Crescent Medical Journal،Vol. 17, no. 2, pp.1-5.
https://search.emarefa.net/detail/BIM-533234
Modern Language Association (MLA)
Asfahani, Zubaydah Rajezi…[et al.]. Monoamine oxidase a gene polymorphisms and bipolar disorder in Iranian population. Iranian Red Crescent Medical Journal Vol. 17, no. 2 (Feb. 2015), pp.1-5.
https://search.emarefa.net/detail/BIM-533234
American Medical Association (AMA)
Asfahani, Zubaydah Rajezi& Davari-Ashtiani, Rozita& Khademi, Mo-Mojgan& Emamalizadeh, Babak& Movafagh, Abu al-Fadl& Sadr, Said…[et al.]. Monoamine oxidase a gene polymorphisms and bipolar disorder in Iranian population. Iranian Red Crescent Medical Journal. 2015. Vol. 17, no. 2, pp.1-5.
https://search.emarefa.net/detail/BIM-533234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4-5
Record ID
BIM-533234