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Childhood lymphoblastic lymphoma : hospital based study
Joint Authors
al-Haddad, Salma A.
Fadl, Samahir A.
al-Darraji, Amir F.
al-Sayyid, Raghad M.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 56, Issue 4 (31 Dec. 2014), pp.352-356, 5 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2014-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Lymphoblastic lymphomas (LBL) are neoplasms of precursor T cells and B cells, or lymphoblasts.
The term lymphoblastic lymphoma has been used to describe predominantly lymph node-based disease ; however, clinical distinction between LBL and acute lymphoblastic leukemia (ALL) has been arbitrary and has varied among different studies and institutions.
Objectives : To determine the frequency of LBL among all Non-Hodgkin’s lymphoma (NHL) patients in children and to study the clinical and pathological features of LBL and assess the treatment outcome.
Methods : A retrospective study included 28 children with newly diagnosed LBL (based on morphology) below the age of 14 years over 8 years period from January 1st, 2000 to December 31st, 2007 All the patients except one were treated by modified Medical Research Council UK National Randomized Trial For Children and young Adult with Acute Lymphoblastic Leukemia (MRC UKALL) regimen, one patient was misdiagnosed as B-cell NHL and treated with United Kingdom Children’s Cancer Study Group (UKCCSG) Non-Hodgkin’s Lymphoma protocol.
Results : LBL forms 28 / 376 (7.1 %) among NHL diagnosed in Children Welfare Teaching Hospital (CWTH) in the same period.
The median age was 8.95 years (range 2 to 13.25 years) with male to female ratio of 3.7:1.
Lymphadenopathy was present in 22 (78 .6 %) of patients.
The median duration of onset of symptoms was 7.25 months (range 1 week to 18 months).
In response to treatment, 20 (71.4 %) patients achieved complete remission (CR), 1 (3.6 %) died during induction and 7 (25 %) patients were non-responder (4 died and 3 abandoned).
Of the 20 patients who achieved complete remission (CR) ; thirteen (46.4 %) remained in continuous complete remission with a median follow up of 32.3 months, 3 (10.7 %) patients died while in CR in an average of 16.6 weeks, 2 (7.1 %) patients abandoned treatment and 2 (7.1 %) patients relapsed.
Conclusion : The study showed a low frequency of LBL in comparison with other studies which might be due to inadequate diagnostic facilities which differentiate LBL from other types of NHL, low survival rate might be due to advanced stages at presentation in addition to abandonment of treatment in some patients.
American Psychological Association (APA)
Fadl, Samahir A.& al-Darraji, Amir F.& al-Sayyid, Raghad M.& al-Haddad, Salma A.. 2014. Childhood lymphoblastic lymphoma : hospital based study. Journal of the Faculty of Medicine Baghdad،Vol. 56, no. 4, pp.352-356.
https://search.emarefa.net/detail/BIM-533286
Modern Language Association (MLA)
Fadl, Samahir A.…[et al.]. Childhood lymphoblastic lymphoma : hospital based study. Journal of the Faculty of Medicine Baghdad Vol. 59, no. 4 (2014), pp.352-356.
https://search.emarefa.net/detail/BIM-533286
American Medical Association (AMA)
Fadl, Samahir A.& al-Darraji, Amir F.& al-Sayyid, Raghad M.& al-Haddad, Salma A.. Childhood lymphoblastic lymphoma : hospital based study. Journal of the Faculty of Medicine Baghdad. 2014. Vol. 56, no. 4, pp.352-356.
https://search.emarefa.net/detail/BIM-533286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 355-356
Record ID
BIM-533286