Biochemical parameters among type 2 diabetic patients with erectile dysfunction in Gaza City

Other Title(s)

المعايير البيوكيميائية عند مرضى السكر النوع الثاني المصاحب لعدم القدرة على الانتعاظ (الانتصاب)‎ في مدينة غزة

Dissertant

al-Rai, Dhib Jumah Dhib

Thesis advisor

Shubayr, Muhammad Id

Comitee Members

Farwanah, Umar Salih
Sardah, Mahmud Muhammad

University

Islamic University

Faculty

Faculty of Science

Department

Department of Biological Science

University Country

Palestine (Gaza Strip)

Degree

Master

Degree Date

2014

English Abstract

Background: Patients with type 2 diabetes mellitus (DM2) are more often have disturbances of sexual and reproductive functions.

There is increasing recognition that hypotestosteronaemia is associated with DM2, cardiovascular disease (CVD), visceral obesity, insulin resistance (IR) and dyslipidemia.

Objectives: The main objective of this study is to investigate biochemical parameters in DM2 patients with erectile dysfunction (ED) in Gaza city.

Materials and Methods: This study is a case control study, and was carried out in Gaza city during the period (April to October, 2013).

A total of 160 males aged 35 – 60 years were recruited; 80 DM2 patients and 80 as controls.

Anthropometric, demographic, sexual and clinical data were obtained by questionnaire.

Ten ml of blood were obtained for determination of fasting blood glucose (FBG), cholesterol, triglycerides and high density lipoprotein-cholesterol (HDL-C).

Glycated hemoglobin (HbA1c) was determined.

Testosterone and insulin levels were analyzed by enzyme immunoassay.

Low density lipoprotein-cholesterol (LDL-C) and homeostasis model assessment for insulin resistance (HOMA-IR) were calculated.

Ethical approval was obtained.

Data were analyzed using statistical package for social sciences (SPSS) software version 18 to find association, correlation and relationships.

Results: Increased prevalence of high BMI and HOMA-IR was observed among DM2 patients, in addition to high prevalence of low testosterone level (p < 0.05).

Testosterone was correlated negatively and significantly with BMI and duration of DM2 (p < 0.05).

ED was correlated significantly and directionally with duration of DM2, and complications of diabetes (p < 0.05).

While, nocturnal/early morning erection (NEME) was correlated V significantly but inversely with duration of DM2 (p < 0.05).

In addition, duration of DM2 and low level of testosterone could be used as predictor factors associated with ED (p < 0.05), while increased BMI was a predictor factor associated with low testosterone level (p < 0.05).

Conclusion: In the present study, high incidence of low testosterone and increased prevalence of ED among DM2 patients could be attributed to uncontrolled DM2, obesity, IR, dyslipidemia, complications and long duration of DM2.

Keywords: Type 2 diabetes mellitus, erectile dysfunction, insulin resistance, obesity, dyslipidemia, Gaza.

Main Subjects

Medicine

Topics

• Pathology
• Pathogens
• Palestine
• Gaza Strip
• Type 2 diabetes

No. of Pages

98

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-533807