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Retrospective case-control : study of the outcome of pregnancy after paternal leukocytes transfusion in cases of recurrent pregnancy loss
Joint Authors
Sad, F. A.
Rizvi, Z.
Sharara, H. A.
Source
Issue
Vol. 6, Issue 1 (30 Nov. 1997), pp.30-33, 4 p.
Publisher
Publication Date
1997-11-30
Country of Publication
Qatar
No. of Pages
4
Main Subjects
Abstract EN
Immunization therapy, for treatment of recurrent pregnancy loss (RPL), has been developed since the mid-1980's.
The effect of this kind of therapy is still controversial The purpose of this retrospective, case-control study, was to evaluate the beneficial effect of immunotherapy for the treatment of patients with RPL and negative antipaternal cytotoxic antibodies.
During a 3-year period (1992 to 1994), we were able to collect 25 such patients who conceived after having been immunized abroad.
We compared the outcome of the pregnancies of those 25 patients with that of 41 unimmunized patients used as controls.
There was no statistically significant difference between the two groups regarding maternal age, parity, number of previous abortions, gestational age, infant weight, and Apgar score at 5 minutes.
The pregnancy success rate was higher in patients who were not immunized (80.5%) than in those who were immunized (56%).
The difference bordered on, but did not reach, statistical significance (P=0.064).
There was no significant difference whether immunization was performed before or during pregnancy or whether pregnancy occurred within 26 weeks of immunization or between 27 and 52 weeks.
The only significant difference between the two groups was related to the drugs (Aspirin and progesterone) used in the antenatal period and this may explain the higher; although not significant, success rate in the control group.
It is not yet clear whether immunotherapy has any substantial effect in preventing recurrent abortions.
More controlled prospective studies are required to reach a final conclusion regarding this form of treatment.
American Psychological Association (APA)
Sad, F. A.& Rizvi, Z.& Sharara, H. A.. 1997. Retrospective case-control : study of the outcome of pregnancy after paternal leukocytes transfusion in cases of recurrent pregnancy loss. Qatar Medical Journal،Vol. 6, no. 1, pp.30-33.
https://search.emarefa.net/detail/BIM-534863
Modern Language Association (MLA)
Sad, F. A.…[et al.]. Retrospective case-control : study of the outcome of pregnancy after paternal leukocytes transfusion in cases of recurrent pregnancy loss. Qatar Medical Journal Vol. 6, no. 1 (Nov. 1997), pp.30-33.
https://search.emarefa.net/detail/BIM-534863
American Medical Association (AMA)
Sad, F. A.& Rizvi, Z.& Sharara, H. A.. Retrospective case-control : study of the outcome of pregnancy after paternal leukocytes transfusion in cases of recurrent pregnancy loss. Qatar Medical Journal. 1997. Vol. 6, no. 1, pp.30-33.
https://search.emarefa.net/detail/BIM-534863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 33
Record ID
BIM-534863