Uric acid curve : an evidence of in influence of serum oestrogen level on serum uric acid

Abstract EN

During the fertile age women showed a lower serum urate than men of similar ages .

The intersexual difference is thought to be related to a higher renal clearance of urate possibly due to their higher plasma estrogen level.

We correlat- ed between the cyclic changes ofS.

estrogen and S.

uric acid during menstrual cycle .

S.

estrogen and S.

Uric acid were estimated at days 1, 7, 14, 21, and 28 of menstrual cycle in 20 normal age-fertile non married women .

The progressive rise of S.

estrogen in the 1st half of the menstrual cycle was accompanied by a progres- sive decrease of S.

uric acid and its progressive decrease in the 2 nd.

half was accompanied by a progressive increase in S.

uric acid.

S.

Uric acid changes were plotted as a curve which is nearly a mirror of the S.

estrogen curve and so it could be used to give an idea about the physiologic estrogen curve in females .

The cor- relation test between the two curves indicated that the suggested influence of S.

estrogen on S.

Uric acid is neither direct nor absolute, perhaps through a physio- logical mechanism including more than one factor in addition to S.

estrogen .